CUHK_CCT00373
2013-07-04
Prospective
CRE_2012.175-T
RGC
The Chinese University of Hong Kong
NIL
Hazel Mok
Department of Medicine and Therapeutics, PWH
2632 3990
hazelmok@cuhk.edu.hk
The Chinese University of Hong Kong
Prof. Timothy Kwok
Department of Medicine and Therapeutics, PWH
2632 3145
tkwok@cuhk.edu.hk
The Chinese University of Hong Kong
The use of B vitamins to prevent cognitive decline in older mild cognitive impairment patients with elevated plasma homocysteine – A randomized placebo controlled trial
The use of B vitamins to prevent cognitive decline in older mild cognitive impairment patients with elevated plasma homocysteine – A randomized placebo controlled trial
服用維他命B為有輕度認知障礙和高〝同型半胱氨酸〞血漿水平的長者預防智力衰退 - 安慰劑隨機抽樣對照臨床研究
NA
Hong Kong
Yes
2012-06-06
Dementia
Drug
Vitamin B12 and Folic acid
24 months
Vitamin B12 and Folic acid in intervention group. Placebo in control group
1. Age ≥ 70 years old
2. Clinical diagnosis of MCI
3. Homocysteine ≥ 13µmol/L
4. Caregiver (personal contact at least once a week)
1. Demenita
2. Hypothyroidism
3. B12 < 150 pmol/L
4. Folate < 9.5 nmol/L
5. Creatinine > 200 µmol/L
70
NIL
Both Male and Female
Interventional
Randomized
Active
Double-blind
Parallel
2013-08-01
336
Not Yet Recruiting
Cognitive improvement (CDR score)
CDR sum of scores, neurocognitive test, depression scale
2015-03-31
Yes
NIL
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