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Trial History Detail on 2011-04-06

CUHK_CCT00101

2006-04-12

Retrospective

None

Departmental Sources

Dept of Anaesthesia and Inteneive Care, CUHK

Nil

Manoj K Karmakar

Dept of Anaesthesia and Intensive Care, CUHK

26321311

karmakar@cuhk.u.hk

Associate Professor

Manoj K Karmakar

Dept of Anaesthesia and Intensive Care, CUHK

26321311

karmakar@cuhk.u.hk

Associate Professor

Comparative pharmacokinetics after thoracic paravertebral administration of levobupivacaine with or without epinephrine

Professor

Pharmacokinetics of levobupivacaine after thoracic paravertebral block

Hong Kong

Yes

2002-07-11

nil

Drug

Plain levobupivacaine or levobupivacaine with epinephrine

Single (pre incisional) injection

Levobupivacaine or Levobupivacaine with epinephrine

Inclusion: All consenting adult ASA (American Society of Anaesthesiologists) class 1-3 patients under the age of 75 years who are due to receive a thoracic paravertebral block as part of their routine perioperative management will be recruited for this study.

Exclusion: The following patients will be excluded from the study: 1. Patients with a known allergy to local anaesthetic drugs. 2. Patient with infection at the site of block placement. 3. Patient with a bleeding tendency or evidence of coagulopathy. 4. Patient with pre-existing neurological or muscular disorders. 5. Patients with deranged liver or renal function.

20

60

Both Male and Female

Interventional

Randomized

Placebo

Double-blind

Parallel

2002-08-01

20

Complete

Pharmacokinetics variable Cpmax

Tmax, Vd, Cl, T1/2 and MBRT over 24 hours

No

2011-04-06

ChiCTR-TRC-09000685

2010-05-04


Yes

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