CUHK_CCT00101
2006-04-12
Retrospective
None
Departmental Sources
Dept of Anaesthesia and Inteneive Care, CUHK
Nil
Manoj K Karmakar
Dept of Anaesthesia and Intensive Care, CUHK
26321311
karmakar@cuhk.u.hk
Associate Professor
Manoj K Karmakar
Dept of Anaesthesia and Intensive Care, CUHK
26321311
karmakar@cuhk.u.hk
Associate Professor
Comparative pharmacokinetics after thoracic paravertebral administration of levobupivacaine with or without epinephrine
Professor
Pharmacokinetics of levobupivacaine after thoracic paravertebral block
Hong Kong
Yes
2002-07-11
nil
Drug
Plain levobupivacaine or levobupivacaine with epinephrine
Single (pre incisional) injection
Levobupivacaine or Levobupivacaine with epinephrine
Inclusion: All consenting adult ASA (American Society of Anaesthesiologists) class 1-3 patients under the age of 75 years who are due to receive a thoracic paravertebral block as part of their routine perioperative management will be recruited for this study.
Exclusion: The following patients will be excluded from the study: 1. Patients with a known allergy to local anaesthetic drugs. 2. Patient with infection at the site of block placement. 3. Patient with a bleeding tendency or evidence of coagulopathy. 4. Patient with pre-existing neurological or muscular disorders. 5. Patients with deranged liver or renal function.
20
60
Both Male and Female
Interventional
Randomized
Placebo
Double-blind
Parallel
2002-08-01
20
Complete
Pharmacokinetics variable Cpmax
Tmax, Vd, Cl, T1/2 and MBRT over 24 hours
2011-04-06
ChiCTR-TRC-09000685
2010-05-04
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