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Trial History Detail on 2013-09-11

CUHK_CCT00100

2006-04-12

Retrospective

not applicable

Departmental

Department of Anaesthesia and Intensive Care

None

Manoj K Karmakar

Department of Anaesthesiaand Inteneive Care, CUHK

+85226321311

karmakar@cuhk.edu.hk

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital

Manoj K Karmakar

Department of Anaesthesia and Intensive Care, CUHK

+85226321311

karmakar@cuhk.edu.hk

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital

Continuous Thoracic Paravertebral Block: Effects on Acute and Chronic Pain and Quality of Life after Breast Cancer Surgery.

Continuous Thoracic Paravertebral Block: Effects on Acute and Chronic Pain and Quality of Life after Breast Cancer Surgery - A 5 year follow up.

Effects of Thoracic paravertebral block on acute and chronic pain after breast surgery

Hong Kong

Yes

2004-12-14

Chronic Pain and Quality of Breast Cancer Surgery

Other

Thoracic paravertebral block before surgery, postoperative follow up, telephone interview

Thoracic paravertebral block done before surgery, postoperative 3 days ward follow-up, 1 and 3 months telephone interview for acute pain data. Telephone interview once per year for 5 years for the incidence of chronic pain condition and quality of life after surgery.

5 years follow up after date of surgery

Patients are randomized into 3 groups: Control group, placebo paravertebral infusion group, Ropivacaine paravertebral infusion group

Inclusion: Consenting adult ASA 1-3 patients under the age of 70 years undergoing major breast cancer surgery (which includes axillary lymph node dissection) will be recruited for this study.

Exclusion: The following patients will be excluded from the study: history of chronic pain, history of regular analgesic usage, contraindication to the use of non-steroidal anti-inflammatory drugs (NSAID), known allergy to local anaesthetic drugs, infection at the site of block placement, bleeding tendency or with evidence of coagulopathy, pre-existing neurological or muscular disorders, history of psychiatric illness, pregnant patients, pre-existing nausea or vomiting, patients who in the 24 h before surgery received opioid or drugs with antiemetic properties, patients who received chemotherapy or radiotherapy before surgery and patients with breast pain before surgery.

18

70

Female

Interventional

Randomized

Placebo

Double-blind

Parallel

2005-04-01

180

Complete

Data collection on aucte pain and quality of life at 1 and 3 months after surgery are finished.
Data collection of the incidence of chronic pain and quality of life after breast surgery over 5 years are in progress.

Quality of life 5 years after surgery

No

2011-12-12

ChiCTR-TRC-06000684

2010-05-04


Yes

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