CUHK_CCT00096
2006-01-27
Prospective
Departmental
None
Matthew Chan
Department ofAnaesthesia and Intensive Care
mtvchan@cuhk.edu.hk
Matthew Chan
Department ofAnaesthesia and Intensive Care
mtvchan@cuhk.edu.hk
Combination of Aprepitant and Dexamethasone to Prevent Postoperative Nausea and Vomiting
Yes
2005-11-01
Anesthesia
Drug
Aprepitant
Immediately before induction of anesthesia
Dexamethasone and a combination of Aprepitant and Dexamethasone
Inclusion criteria: All women (age 18-65 years) undergoing open gynecologic surgery will be eligible Exclusion criteria: (1) Patients had preexisting nausea or vomiting (2) Patients had received opioids or drugs with known antiemetic properties in the 24 hours before surgery. (3) Pregnant patients (4) Patients with history of esophageal reflux, opioid or alcohol abuse.
Randomized
Placebo
Double-blind
Factorial
2006-02-01
320
Recruiting
Complete response (no vomiting, no nausea, no rescue antiemetic)
QoR,FLIE questionnaire, Pain and nausea score
2009-11-27
Yes
None
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