CUHK_CCT00073
2005-09-13
Retrospective
HHSRF
HHSRF
Matthew Chan
Dept Anaesthesia and Intensive Care, CUHK
mtvchan@cuhk.edu.hk
Matthew Chan
Dept Anaesthesia and Intensive Care, CUHK
mtvchan@cuhk.edu.hk
Evaluation of Nitrous oxide In the Gas Mixture for Anesthesia: a randomized controlled Trial
The ENIGMA trial
Yes
2003-01-16
Quality of recovery
Drug
Nitrous oxide
Intraoperative peroid
Nitrous oxide administration
Inclusion Criteria: 1. Males and females, age 18 years and over 2. Planned general anesthesia for surgery that includes a skin incision and expected to exceed two hours, and the patient is expected to be in hospital for at least three days
Exclusion Criteria: 1. Endoscopic or radiological procedures 2. Cardiac surgery 3. Marked impairment of gas-exchange (requiring FiO2 > 0.3) 4. Thoracic surgery requiring one-lung ventilation (requiring FiO2 > 0.3) 5. Specific circumstances where N2O is contraindicated (eg. volvulus, pulmonary hypertension, raised intracranial pressure) 6. Lack of provision of N2O.
Randomized
Placebo
Double-blind
Parallel
2004-01-01
2000
Complete
Length of hospital stay
Perioperative complications Endothelial reactivity COMET assay
2007-09-15
ChiCTR-TRC-05000656
2010-05-04
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