CUHK_CCT00053
2005-09-09
Retrospective
None
Pfizer
Department of Medicine & Therapeutics, The Chinese University of Hong Kong
Boston Scientific
Leata Yeung
Department of Medicine & Therapeutics, The Chinese University of Hong Kong
2632 3841
leata@cuhk.edu.hk
CUHK
Prof Cheuk Man Yu
Department of Medicine & Therapeutics, The Chinese University of Hong Kong
2632 3136
cmyu@cuhk.edu.hk
CUHK
Atherosclerotic plaque burden reduction in Native and Intervened coronary arteries as well as in other Major arteries by High Dose ATorvastatin ThErapy-A double blind, randomized study (ANIMATE)
Atherosclerotic plaque burden reduction in Native and Intervened coronary arteries as well as in other Major arteries by High Dose ATorvastatin ThErapy-A double blind, randomized study (ANIMATE)
ANIMATE
HONG KONG
Yes
2003-07-03
Heart and Blood Vessel Diseases
Drug
Ischaemic Heart Disease Patients
6 Months
Atorvastatin 10 mg or 80 mg daily
Inclusion criteria: *Patient with established CAD indicated for PCI *Plasma LDL-cholesterol level >2.6mmol/L or clinically indicated for statin therapy
Exclusion criteria: *Significant renal failure that preclude coronary angiography and PCI *Significant left main CAD with significant risk to IVUS *Less than 6 months survival
>18
N/A
Both Male and Female
Interventional
Randomized
Dose comparison
Double-blind
Parallel
2003-07-03
140
Complete
• Atherosclerotic plaque burden by IVUS in the diseased native coronary artery that does not require PC1** • Atherosclerotic plaque burden by IVUS and restenosis by both IVUS and QCA for the degree of neointimal hyperplasia in the post-PCI coronary artery • Neointimal thickness of the carotid and brachial artery • Brachial artery dilatation in response to hyperaemia, i.e. the flow-depend dilatation as an indicator of endotheial function **only apply to the IVUS arm
• Coronary diameter and percentage stenosis by QCA • Cardiovascular event rate • Correlation of the degree of atherosclerotic plaque regression to symptoms and cardiovascular event rate
2009-11-27
ChiCTR-TRC-09000649
2010-05-04
Yes
N/A
|
|
|
|
|
---|---|---|---|---|
No documents yet. |