CUHK_CCT00051
2005-09-09
Retrospective
None
Takeda Chemical Industries, LTD
Department of Medicine & Therapeutics, The Chinese University of Hong Kong
N/A
Leata Yeung
Department of Medicine & Therapeutics, The Chinese University of Hong Kong
2632 3841
leata@chuk.edu.hk
CUHK
Prof. John E. Sanderson
Department of Medicine & Therapeutics, The Chinese University of Hong Kong
37636050
jesanderson@cuhk.edu.hk
Honorary Professor of Cardiology, CUHK
The effect of angiotensin receptor blockade alone or in combination with spironolactone on the process of ventricular remodeling in chronic heart failure.
The effect of angiotensin receptor blockade alone or in combination with spironolactone on the process of ventricular remodeling in chronic heart failure.
None
Hong Kong
Yes
2001-07-03
Heart and Blood Vessel Diseases
Drug
Heart Failure Patients
one year
Candesartan + Spirolactone verus Candesartan + Placebo
Inclusion criteria *Typical features of congestive heart failure. *LVEF < 40%.
Exclusion criteria *Patients with renal failure, serum creatinine > 200 mmol/ltr. *Other major serious medical conditions such as malignancy, liver failure, uncontrolled diabetes. Gender and age will be balanced in the two randomized groups.
none
none
Both Male and Female
Interventional
Randomized
Placebo
Double-blind
Parallel
2001-10-08
50
Complete
We sought to determine the beneficial effect of candesartan alone or in combination with spironolactone on left ventricular remodelling
N/A
2009-12-28
ChiCTR-TRC-09000648
2010-05-04
Yes
N/A
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