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Trial History Detail on 2011-02-08

CUHK_CCT00051

2005-09-09

Retrospective

None

Takeda Chemical Industries, LTD

Department of Medicine & Therapeutics, The Chinese University of Hong Kong

N/A

Leata Yeung

Department of Medicine & Therapeutics, The Chinese University of Hong Kong

2632 3841

leata@chuk.edu.hk

CUHK

Prof. John E. Sanderson

Department of Medicine & Therapeutics, The Chinese University of Hong Kong

37636050

jesanderson@cuhk.edu.hk

Honorary Professor of Cardiology, CUHK

The effect of angiotensin receptor blockade alone or in combination with spironolactone on the process of ventricular remodeling in chronic heart failure.

The effect of angiotensin receptor blockade alone or in combination with spironolactone on the process of ventricular remodeling in chronic heart failure.

None

Hong Kong

Yes

2001-07-03

Heart and Blood Vessel Diseases

Drug

Heart Failure Patients

one year

Candesartan + Spirolactone verus Candesartan + Placebo

Inclusion criteria *Typical features of congestive heart failure. *LVEF < 40%.

Exclusion criteria *Patients with renal failure, serum creatinine > 200 mmol/ltr. *Other major serious medical conditions such as malignancy, liver failure, uncontrolled diabetes. Gender and age will be balanced in the two randomized groups.

none

none

Both Male and Female

Interventional

Randomized

Placebo

Double-blind

Parallel

2001-10-08

50

Complete

We sought to determine the beneficial effect of candesartan alone or in combination with spironolactone on left ventricular remodelling

N/A

No

2009-12-28

ChiCTR-TRC-09000648

2010-05-04


Yes

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