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Trial History Detail on 2014-06-30

CUHK_CCT00373

2013-07-04

Prospective

CRE_2012.175-T

RGC

The Chinese University of Hong Kong

NIL

Hazel Mok

Department of Medicine and Therapeutics, PWH

2632 3990

hazelmok@cuhk.edu.hk

The Chinese University of Hong Kong

Prof. Timothy Kwok

Department of Medicine and Therapeutics, PWH

2632 3145

tkwok@cuhk.edu.hk

The Chinese University of Hong Kong

The use of B vitamins to prevent cognitive decline in older mild cognitive impairment patients with elevated plasma homocysteine – A randomized placebo controlled trial

The use of B vitamins to prevent cognitive decline in older mild cognitive impairment patients with elevated plasma homocysteine – A randomized placebo controlled trial

服用維他命B為有輕度認知障礙和高〝同型半胱氨酸〞血漿水平的長者預防智力衰退 - 安慰劑隨機抽樣對照臨床研究

NA

Hong Kong

Yes

2012-06-06

Dementia

Drug

Vitamin B12 and Folic acid

24 months

Vitamin B12 and Folic acid in intervention group. Placebo in control group

1. Age ≥ 65 years old
2. Clinical diagnosis of MCI
3. Homocysteine ≥ 10µmol/L
4. Caregiver (personal contact at least once a week)

1. Demenita
2. Hypothyroidism
3. B12 < 150 pmol/L
4. Folate < 9.5 nmol/L
5. Creatinine > 200 µmol/L

65

NIL

Both Male and Female

Interventional

Randomized

Active

Double-blind

Parallel

2013-08-01

336

Not Yet Recruiting

Cognitive improvement (CDR score)

CDR sum of scores, neurocognitive test, depression scale

No

2015-03-31

ChiCTR-TRC-13003302

2013-07-04


Yes

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