CUHK_CCT00320
2012-05-17
Prospective
Nil
Nil
Nil
Nil
Alex Pui Wai LEE
Division of Cardiology, Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong
852-2632 3140
alexpwlee@cuhk.edu.hk
Department of Medicine & Therapeutics, The Chinese Univerity of Hong Kong
Qing SHANG
Division of Cardiology, Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong
852-2632 3840
qingshang@cuhk.edu.hk
Department of Medicine & Therapeutics, The Chinese Univerity of Hong Kong
Cardiovascular Reserve in Patients with Systemic Autoimmune Diseases
Cardiovascular Reserve in Patients with Systemic Autoimmune Diseases
Nil
Hong Kong SAR, China
Yes
2012-03-21
Rheumatic diseases
Other
None
N/A
N/A
N/A
Patients with SLE or PsA, Control subjects who are considered to have a low probability of coronary artery disease on clinical grounds and have a normal exercise stress echocardiogram.
Exclusion criteria are uncontrolled severe hypertension (Resting systolic blood pressure is 180mmHg or greater or diastolic blood pressure is 120mmHg or higher), significant atrial or ventricular arrhythmia, significant valvular diseases (>moderate severity), significant coronary artery disease, prior history of myocardial infarction, impaired LV systolic function (ejection fraction<50%, or any regional wall motion abnormality), pericardial disease and unable to exercise.
18 years
N/A
Both Male and Female
Observational
Non-randomized
Not Applicable
Not Applicable
Parallel
2012-07-04
150
Unknown
1. Changes in resting cardiac function and functional reserve during exercise in 3-dimensional planes
2. Increased arterial stiffness in resting and impaired vascular reserve during exercise
3. Association among early cardiovascular dysfunction, impaired functional reserve during exercise and biomarkers
N/A
2014-11-24
ChiCTR-ONC-12002365
2012-07-22
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