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Trial History Detail on 2011-04-01

CUHK_CCT00027

2005-09-06

Retrospective

CRE-2002.376.T

The Chinese University of Hong Kong

The Chinese University of Hong Kong

n/a

Dr. SZETO Cheuk Chun

Department of Medicine & Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong

85226323146

ccszeto@cuhk.edu.hk

Department of Medicine & Therapeutics, CUHK

Dr. SZETO Cheuk Chun

Department of Medicine & Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong

85226323126

ccszeto@cuhk.edu.hk

Department of Medicine & Therapeutics, CUHK

Treatment of Early Immunoglobulin A Nephropathy by the Angiotensin Converting Enzyme Inhibitor Ramipril - A Randomized Controlled Trial

Treatment of Early Immunoglobulin A Nephropathy by the Angiotensin Converting Enzyme Inhibitor Ramipril - A Randomized Controlled Trial

Ramipril for early IgAN

Hong Kong

Yes

2002-11-06

IgA nephropathy

Drug

ramipril

5 years

no treatment

Inclusion criteria are: • age between 18 and 65 • biopsy-confirmed IgA nephropathy • proteinuria less than 0.5 g per day, normal blood pressure, and serum creatinine below 120 ƒÝmol/l • willingness to give written informed consent and willingness to participate in and comply with the study protocol

Exclusion criteria are: • expected survival less than 2 years • pregnant or nursing mother, or women of childbearing potential without an effective method of birth control • history of myocardial infarction, congestive heart failure, or any other medical indication that necessitate the use of ACE inhibitor • evidence of clinically significant hepatic, gastrointestinal, autoimmune disease • history of malignancy, drug or alcohol abuse • participation in any previous trial on ACE inhibitor • taking other investigational drugs within the past 30 days • history of non-compliance to medical regimens and patients who are considered potentially unreliable • known history of sensitivity / allergy to ACE inhibitor

18

80

Both Male and Female

Interventional

Randomized

Placebo

Open label

Parallel

2004-01-01

60

Complete

• development of hypertension (defined as blood pressure above 140/90 mm Hg and require anti-hypertensive therapy) • development of proteinuria „d 1 g per day • 20% decline in creatinine clearance, as determined by 24-hour urine collection or estimated by the Gault-Cockroft equation

n/a

No

2011-04-01

ChiCTR-TRC-09000630

2010-05-04


Yes

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