CUHK_CCT00027
2005-09-06
Retrospective
CRE-2002.376.T
The Chinese University of Hong Kong
The Chinese University of Hong Kong
n/a
Dr. SZETO Cheuk Chun
Department of Medicine & Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong
85226323146
ccszeto@cuhk.edu.hk
Department of Medicine & Therapeutics, CUHK
Dr. SZETO Cheuk Chun
Department of Medicine & Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong
85226323126
ccszeto@cuhk.edu.hk
Department of Medicine & Therapeutics, CUHK
Treatment of Early Immunoglobulin A Nephropathy by the Angiotensin Converting Enzyme Inhibitor Ramipril - A Randomized Controlled Trial
Treatment of Early Immunoglobulin A Nephropathy by the Angiotensin Converting Enzyme Inhibitor Ramipril - A Randomized Controlled Trial
Ramipril for early IgAN
Hong Kong
Yes
2002-11-06
IgA nephropathy
Drug
ramipril
5 years
no treatment
Inclusion criteria are: • age between 18 and 65 • biopsy-confirmed IgA nephropathy • proteinuria less than 0.5 g per day, normal blood pressure, and serum creatinine below 120 Ýmol/l • willingness to give written informed consent and willingness to participate in and comply with the study protocol
Exclusion criteria are: • expected survival less than 2 years • pregnant or nursing mother, or women of childbearing potential without an effective method of birth control • history of myocardial infarction, congestive heart failure, or any other medical indication that necessitate the use of ACE inhibitor • evidence of clinically significant hepatic, gastrointestinal, autoimmune disease • history of malignancy, drug or alcohol abuse • participation in any previous trial on ACE inhibitor • taking other investigational drugs within the past 30 days • history of non-compliance to medical regimens and patients who are considered potentially unreliable • known history of sensitivity / allergy to ACE inhibitor
18
80
Both Male and Female
Interventional
Randomized
Placebo
Open label
Parallel
2004-01-01
60
Complete
• development of hypertension (defined as blood pressure above 140/90 mm Hg and require anti-hypertensive therapy) • development of proteinuria d 1 g per day • 20% decline in creatinine clearance, as determined by 24-hour urine collection or estimated by the Gault-Cockroft equation
n/a
2011-04-01
ChiCTR-TRC-09000630
2010-05-04
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