Prof. Maggie Haitian Wang 王海天

profile photo at cuhk

Dr. Maggie Wang obtained her Bachelor degree (honor) in Physics of the Hong Kong University of Science and Technology (HKUST), and her Doctor in Philosophy degree in Statistics from ISOM department of the HKUST. She joined the Chinese University of Hong Kong as a Research Assistant Professor in 2011. Since 2015 she is an Assistant Professor in the JC School of Public Health and Primary Care.  Dr. Wang is awarded the SH Ho Visiting Professorship Exchange Programme to Stanford University in 2016. She is the Principle Investigator of multiple research grants including the Hong Kong RGC-GRF, and the National Science Foundation of China (NSFC) Projects. She is a member of the Centre for Clinical Research and Biostatistics (CCRB), and the Assistant Director of the Msc program of Epidemiology and Biostatistics.  

Statistical Genetics Research Unit (CCRB-Statgene) website: http://www2.ccrb.cuhk.edu.hk/statgene

Website at SPHPC:  http://www.sphpc.cuhk.edu.hk/maggiew

Research Interests

  • Bioinformatics and statistical genetics: develop new statistical methods and algorithms that provide accurate measure for gene-gene or gene-environmental interactions effects, and incorporate interactions in disease classification problem. Representative publications: Bioinformatics 2017,2012; Nucleic Acids Research 2016
  • Infectious diseases genetic epidemiology: model the pattern of infectious disease epidemics at population level and genetic level, and model genetic sequence evolution. Representative publications: Journal of Infection 2015, 2016

  • Statistical collaborations: from genetic and biomedical data analysis to large multinational epidemiological data analysis. Representative publications: Oncogene 2015; Cancer Research 2016

 

Software developed

  • W-test: for main effect and SNP-SNP interaction association testing in GWAS data (software page)
  • ZFA: for rare variant association tests in NGS data (software)

 

Book Chapter

“Genetic Test, Risk Prediction Model, and Genetic Counselling”, with Haoyi Weng, Book Title: Translational Informatics in Smart Healthcare, Springer, 2016. To appear.

 

Publications (* Corresponding author; + Co-first author, Representative work in bold face)

  1. Maggie Haitian Wang*+, Haoyi Weng+, Rui Sun, Jack Lee, Ka Chun Chong, William K.K. Wu, Benny Chung-Ying Zee* (2017) A Zoom-Focus Algorithm (ZFA) to locate the optimal testing region for rare variant association tests. Bioinformatics.  DOI:10.1093/bioinformatics/btx130 
  2. Maggie Haitian Wang*, Billy Chang, Rui Sun, Inchi Hu, Marc Ka Chun Chong, Benny Chung-Ying Zee*(2017), A Stratified Polygenic Risk Prediction Model with Application on CAGI Bipolar Disorder Sequencing Data. Human Mutation. Accepted
  3. Maggie Haitian Wang*, Steven YF Lau, Chloe Kwok, Ka Chun Chong, Maria Lai, Anthony HY Chung, Chung Shun Ho, Cheuk-Chun Szeto, Benny Chung-Ying Zee (2017). Estimation of chronic kidney disease (CKD) patient clinical parameters by full-scan exhaled breath mass spectrometry data and the IPIS algorithm. Journal of Breath Research. Accepted
  4. Ka Chun Chong, Chi Zhang, Benny Chung Ying Zee, Tongyong Luo, Lei Wang, Greta Chun Huen Tam, Katherine Min Jia, Riyang Sun, Maggie Haitian Wang*, Xuhua Guan (2017) Interpreting the transmissibility of measles in two different post periods of supplementary immunization activities in Hubei, China. Vaccine. Accepted.
  5. Marc Ka Chun Chong, Benny Chung Ying Zee, Maggie Haitian Wang* (2017) A statistical method utilizing information of imported cases to estimate the transmissibility for an influenza pandemic. BMC Medical Research Methodology. Accepted.
  6. Ruoting Men, Maoyao Wen, Mingyue Zhao, Xuelian Dan, Zongze Yang, Wenchao Wu, Maggie Haitian Wang, Xiaojing Liu, Li Yang (2017) MircoRNA-145 promotes activation of hepatic stellate cells via targeting krüppel-like factor 4. Scientific Reports. Accepted.
  7. Maggie Haitian Wang*+, Rui Sun+, Junfeng Guo, Haoyi Weng, Jack Lee, Inchi Hu, Pak Sham and Benny C.Y. Zee* (2016). A fast and powerful W-test for pairwise epistasis testing. Nucleic Acids Research. doi:10.1093/nar/gkw347
  8. Rui Sun, Haoyi Weng, Inchi Hu, Junfeng Guo, William K.K. Wu, Benny Chung-Ying Zee, Maggie Haitian Wang* (2016) A W-test collapsing method for rare variant association testing in exome sequencing data. Genetic Epidemiology. DOI: 10.1002/gepi.22000. 
  9. Maggie Haitian Wang+, Ka Chun Chong+, Hau Yin Chung, Malina Storer, John Pickering, Zoltan Endre, Steven Lau, Chloe Kwok, Maria Lai, Benny Zee (2016). Use of a Least Absolute Shrinkage and Selection Operator (LASSO) Model to Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) Analysis of Exhaled Breath to Predict the Efficacy of Dialysis. Journal of Breath Research 10 (2016) 046004. 
  10. Yaqing He, Linjie Zou, Marc Chong, Ruoting Men, Wenbo Xu, Hong Yang, Xiangjie Yao, Long Chen, Huixia Xian, Hailong Zhang, Min Luo, Jinquan Cheng, Hanwu Ma, Qianjin Feng, Yun Huang, Yujie Wang, Eng-kiong Yeoh, Benny Zee, Yuanping Zhou, Ming-Liang He and Maggie Haitian Wang* (2016) Genetic Evolution of Human Enterovirus A71 Subgenotype C4 in Shenzhen, China, 1998-2013. Journal of Infection. doi:10.1016/j.jinf.2016.03.014. 
  11. Chunli Wu+, Maggie Haitian Wang+, Xing Lu, Ka Chun Chong, Jason He, Chun-Yip Yau, Mark Hui, Xiaowen Cheng, Li Yang, Benny Chung-Ying Zee, Renli Zhang, and Ming-Liang He (2016) Concurrent epidemics of influenza A/H3N2 and A/H1N1pdm in Southern China: a serial cross-sectional study. Journal of Infection. 2016 Mar; 72(3):369-76. doi: 10.1016/j.jinf.2015.12.013. Epub 2015 Dec 30.  
  12. Ho J, Yu J, Wong SH, Zhang L, Liu X, Wong WT, Leung CCH, Choi G, Wang MH, Gin T, Chan MTV*, Wu WKK* (2016) Autophagy in sepsis: Degradation into exhaustion? Autophagy. 
  13. Wu WKK, Li X, Wang X, Dai RZW, Cheng ASL, Wang MHT, Kwong T, Chow TC, Yu J, Chan MTV, Wong SH (2016). Oncogenes without a neighboring tumor-suppressor gene are more prone to amplification. Molecular Biology and Evolution. 
  14. Jeffery Ho, Lin Zhang, Xiaodong Liu, Sunny H Wong, Maggie H T Wang, Benson W M Lau, Shirley P C Ngai, Hung Chan, Gordon Choi, Czarina C H Leung, Wai T Wong, Sharon Tsang, Tony Gin, Jun Yu, Matthew T V Chan, William K K Wu. (2016) Pathological role and diagnostic value of endogenous host defense peptides in adult and neonatal sepsis: a systematic review. Shock 2016 Dec 9. Epub 2016 Dec 9
  15. Jeffery Ho, Hung Chan, Sunny H. Wong, Maggie H. T. Wang, Jun Yu, Zhangang Xiao, Xiaodong Liu, Gordon Choi, Czarina C. H. Leung, Wai T. Wong, Zheng Li, Tony Gin, Matthew T. V. Chan and William K. K. Wu (2016) The involvement of regulatory non-coding RNAs in sepsis: a systematic review. Critical Care 20 (1), 383. 
  16. Hon KL, Kung JSC, Wang Maggie, Leung TF (2016). Clinical scores of sleep loss/pruritus and antihistamine/topical corticosteroid usage for childhood eczema. British Journal of Dermatology
  17. Zhenyu Xu, Jing Shen, Maggie Haitian Wang, Tao Yi, Yangyang Yu, Yinxin Zhu, Bo Chen, Jianping Chen, Longfei Li, Minxing Li, Jian Zuo, Hui Jiang, Dexi Zhou, Jiajie Luan & Zhangang Xiao (2016) Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer. OncoImmunology. 
  18. Biao Zhou, Xuefen Su, Danting Su, Fangfang Zeng, Maggie Haitian Wang, Lichun Huang, Enshan Huang, Yibo Zhu, Dong Zhao, Denghua He, Xuhui Zhu, Engkiong Yeoh, Ronghua Zhang and Gangqiang Ding (2016) Dietary intake of manganese and the risk of the metabolic syndrome in a Chinese population. British Journal of Nutrition
  19. Rui Sun, Qiao Deng, Inchi Hu, Benny C.Y. Zee, Maggie Haitian Wang* (2016) A clustering approach to identify rare variants associated with hypertension. BMC Proc. 2015;9 Suppl 8:S16.
  20. Marc Chong, Xiaoxiao Wang, Shelan Liu, Jian Cai, Xuefen Su, Benny Chung-Ying Zee, Maggie Haitian Wang*, Enfu Chen* (2015) Interpreting the transmissibility of the avian influenza A(H7N9) infection from 2013 to 2015 in Zhejiang province, China. Epidemiology and Infection. 2015 Dec 9:1-8
  21. Weiqin Yang, Myth T. Mok, May S. M. Li, Wei Kang, Maggie Haitian Wang, Anthony W. Chan, Jian-Liang Chou, Jie Chen, Enders K. W. Ng, Ka F. To, Jun Yu, Michael W.Y. Chan, Francis K. L. Chan, Joseph J. Y. Sung, Alfred S. L. Cheng (2015) Epigenetic silencing of GDF1 disrupts SMAD signaling to reinforce gastric cancer development. Oncogene.
  22. Wei-Qin Yang, May S.M. Li, Wei Kang, Li-Han Zeng, Haitian Wang, Anthony W. Chan, Enders K.W. Ng, Ka F. To, Francis K.L. Chan, Jun Yu, Michael W.Y. Chan, Joseph J.Y. Sung, Alfred S.L. Cheng (2015). Reactivation of Growth/Differentiation Factor 1 Contributes to the Chemopreventive Effect of 5-aza-2’deoxycytidine in Gastric Cancer. Clinical Gastroenterology and Hepatology, 1(13), 214.
  23. Bin Jiao, Xiaoyan Liu, Lin Zhou, Maggie Haitian Wang, Yafang Zhou, Tingting Xiao, Weiwei Zhang, Rui Sun, Mary Miu Yee WAYE, Beisha Tang, Lu Shen (2015) Polygenic Analysis of Late-onset Alzheimer Disease From Mainland China. PLoS ONE. 2015; 10(12): e0144898. doi: 10.1371/journal.pone.0144898
  24.  Maggie Haitian Wang, Kelvin Tsoi, Xin Lai, Marc Chong, Tian Zheng, Shaw-Hwa Lo, Benny Zee and Inchi Hu (2015). Two screening methods for genetic association study with application on psoriasis microarray data sets. IEEE International Congress on Big Data. 10.1109/BigDataCongress.2015.55
  25. Marc Chong, Kelvin Tsoi, Maggie Haitian Wang, Benny Zee, Fung Hong, EK Yeoh, Eliza Wong, Carrie Yam, Patsy Chau, Colin Graham (2015). Using a System Dynamic Model to Evaluate the Patient Flow in an Emergency Department of Hong Kong. IEEE International Congress on Big Data 2015. Accepted.
  26. Xin Lai, Liu Liu, Paul B.S. Lai, Kelvin Tsoi, Maggie Haitian Wang, Ka Chun Chong and Benny Zee. Risk-adjusted Monitoring Method for Surgical Data Methodology for Data Analytics (Work in Progress) IEEE International Congress on Big Data 2015. Accepted.
  27. Ka Chun Chong, William Goggins, Benny Chung Ying Zee, Maggie Haitian Wang (2015) Identify Meteorological Drivers for the Seasonal Variations of Influenza Infections in a Subtropical City, Hong Kong. International Journal of Environmental Research and Public Health. ijerph-69059; doi: 10.3390/ijerph120201560
  28. Jin Shen, William K.K. Wu, Maggie H. Wang, Ka F. To, Yangchao Chen, Zhanggang Xiao, May S.M.Li, May S.M. Li, Joanna H. Tong, Wei Kang, Lin Zhang, Lin Wang, Lan Lu, Ruby L.Y. Chan, Jun Yu, Francis K.L. Chan, Joseph J.Y. Sung, Alfred S.L. Cheng, Chi H. Cho (2014) Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis. Cancer Research. canres.1301.2014. 
  29. Maggie Haitian Wang, Jiexin Li, Venus Yeung, Benny Zee, Mary Waye, Suzanne Ho (2014) Gene-gene interactions infer strong risk for type 2 diabetes, obesity and hypertension in Hong Kong Women on candidate genes. Meta Gene. 10.1016/j.mgene.2014.04.010
  30. Lai He+, Jin Zhao+, Maggie Haitian Wang+, Kenny KY Siu, Yong-Xia Gan, Lin Chen, Albert WN Leung, Hsiang-Fu Kung, Benny Zee, Zheng-Rong Yang, Ming-Liang He (2014) Interleukin-27 (IL-27) differentially associated with HIV viral load and CD4+ in HIV monoinfected and HIV/HCV coinfected groups . PLoS ONE, V9(5), e96792.
  31. Maggie Haitian Wang, Chien-Hsun Huang, Tian Zheng, Shaw-Hwa Lo and Inchi Hu (2014) Discovering pure gene-environment interactions in blood pressure genome-wide association studies data: a two-step approach incorporating new statistics. BMC Proceedings. 8(Suppl 1):S62
  32. Michael Agne, Chien-Hsun Huang, Inchi Hu, Maggie Haitian Wang, Tian Zheng, and Shaw-Hwa Lo (2014) Considering Interactive Effects in the Identification of Influential Regions with Extremely Rare Variants via Fixed Bin Approach. BMC Proceedings. 8(Suppl 1):S7
  33. Ruixue Fan, Chien-Hsun Huang, Inchi Hu, Maggie Haitian Wang, Tian Zheng and Shaw-Hwa Lo (2014) A Partition-based Approach to Identify Gene-Environment interactions in Genome Wide Association Studies. BMC Proceedings. 8(Suppl 1):S60
  34. XIE Chen; WANG Zhijun; WANG Charles; XU Jun; WEN Zhining; WANG Haitian; SHI Leming; CHOW S.s. Moses; HUANG Ying and ZUO Zhong. (2013) Utilization of Gene Expression Signature for Quality Control of Traditional Chinese Medicine Formula Si-Wu-Tang. The AAPS Journal vol.15 no.3, pp.884-892. United States of America, 2013.05.24.
  35. Chun-Li Wu+, Juan Lu+, Maggie Haitian Wang+, Xing Lv, Ying Chen, Xin Wang, Hsiang-fu Kung, Benny Zee, Xiao-wen Cheng, Ming-Liang He (2013) Cross sectional survey of influenza antibodies before and during the 2009 pandemic in Shenzhen, China. PLoS ONE 8(1): e53847. doi:10.1371/journal.pone.0053847.
  36. Maggie Haitian Wang, Shaw-Hwa Lo, Tian Zheng and Inchi Hu (2012) A Classification Method Incorporating Interactions among Variables for High-dimensional Data. Bioinformatics (2012) 28 (21): 2834-2842
  37. Nathan Tintle, Hugues Aschard, Inchi Hu, Nora Nock, Haitian Wang and Elizabeth Pugh (2011) Inflated Type I Error Using Aggregation Methods for Rare Variant Data. Genetic Epidemiology, 35, S8.
  38. Haitian Wang, Chien-Hsun Huang, Tian Zheng, Shaw-Hwa Lo and Inchi Hu (2011) New Insights on Old Methods in Identifying Causal Rare Variants, BMC Proceedings. 5 Suppl 9: S50.
  39. Michael Agne, Chien-Hsun Huang, Inchi Hu, Haitian Wang, Tian Zheng and Shaw-Hwa Lo (2011) Identifying influential regions in extremely rare variants using a fixed-bin approach, BMC Proceedings. 5 Suppl 9: S3.

 

Professional Services

 2017 – , Communication committee member, the International Genetic Epidemiology Society (IGES)