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Trial History Detail on 2011-04-04

CUHK_CCT00147

2007-12-18

Prospective

N/A

Departmental

Department of Paediatrics, The Chinese University of Hong Kong

N/A

Albert Martin LI

Department of Paediatrics, PWH, Shatin, Hong Kong

Telephone #: 26322859; Fax #: 26360020;

email: albertm68mcli@yahoo.com

Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong

Albert Martin LI

Department of Paediatrics, PWH, Shatin, Hong Kong

Telephone #: 26322859; Fax #: 26360020;

email: albertm68mcli@yahoo.com

Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong

A randomized controlled study of the effectiveness of azithromycin in preventing post-respiratory syncytial virus bronchiolitis wheezing

A randomized controlled study of the effectiveness of azithromycin in preventing post-respiratory syncytial virus bronchiolitis wheezing

N/A

Hong Kong SAR

Yes

2007-12-11

Post-respiratory syncytial virus bronchiolitis wheezing

Drug

Azithromycin

3 days

Placebo

Inclusion criteria: 1. previously well infants less than or equal to 12 months of age; 2. first episode of wheezing requiring hospitalization, and with a clinical diagnosis of bronchiolitis. Bronchiolitis is diagnosed based on clinical findings including wheezing or wheezing with crackles preceded by upper respiratory tract infection symptoms, and respiratory distress with retractions; 3. admitted in hospital for <24 hours; 4. laboratory confirmed presence of RSV in nasopharyngeal aspirate, and 5. signed written informed consent.

Exclusion criteria: 1. infants with any cardio-respiratory illness, immunodeficiency or were born prematurely (gestational age <37 weeks); 2. infants who had received corticosteroids within 24 hours before presentation; 3. infants who had received antibiotic treatment less than seven days before hospital admission, and 4. infants requiring mechanical ventilation.

term baby (gestational age >=37 weeks)

12 months

Both Male and Female

Observational

Randomized

Placebo

Double-blind

Parallel

2008-02-15

70

Recruiting

The primary outcome is the number of wheezing attacks in the following 12 months after the initial illness.

Secondary outcomes include length of hospital stay (LOS) (in hours) defined as the time between study entry and the actual time that the subject is declared fit for discharge.

No

2013-06-22

ChiCTR-TRC-09000708

2010-05-04


Yes

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