CUHK_CCT00134
2007-08-31
Prospective
ENIGMA 3 study
CERG
CERG
Nil
Matthew Chan
Department of Anaesthesia and Intensive Care, CUHK
26322736
mtvchan@cuhk.edu.hk
The Chinese University of Hong Kong
Matthew Chan
Department of Anaesthesia and Intensive Care, CUHK
26322736
mtvchan@cuhk.edu.hk
The Chinese University of Hong Kong
Evaluation of Nitrous Oxide In the Gas Mixture for Anesthesia Study (The ENIGMA 3 Trial)
NA
The ENIGMA 3 study
Hong Kong
Yes
2006-12-05
Anesthesia
Drug
Nitrous oxide
Intraoperative period
Oxygen
Inclusion 1. Eligible patients are men or women aged ≥18 years, 2. American Society of Anesthesiologists physical status class 1-3, 3. Patients scheduled for major elective abdominal surgeries that require resection of the gastrointestinal tract.
Exclusion 1. Acute bowel obstruction (contraindicated for N2O administration), 2. History of fever or infection ≤24 hours before surgery 3. Marked impairment of gaseous exchange (usually due to severe chronic obstructive pulmonary disease, requiring fiO2>0.4). 4. Surgery with expected duration ≤1 hour or that primary wound closure is not anticipated.
18
90
Both Male and Female
Interventional
Randomized
Placebo
Double-blind
Parallel
2008-01-01
780
Recruiting
Wound infection
(1) Recovery times (2) Intensive Care Unit stay (3) Death due to any cause ≤15 days of surgery.
2011-11-25
ChiCTR-TRC-09000701
2010-05-04
Yes
Nil
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