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Trial History Detail on 2011-03-01

CUHK_CCT00124

2007-04-25

Retrospective

NA

The Chinese University of Hong Kong

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong

N/A

Professor Warwick D. Ngan Kee

Dept of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong

+852 26322735

email warwick@cuhk.edu.hk

The Chinese University of Hong Kong

Professor Warwick D. Ngan Kee

Dept of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong

+852 26322735

email warwick@cuhk.edu.hk

The Chinese University of Hong Kong

Determination and quantification of interactions of local anesthetics and lipophilic opioids administered intrathecally for analgesia:a pharmacodynamic modeling-based approach in labouring parturients

etermination and quantification of interactions of local anesthetics and lipophilic opioids administered intrathecally for analgesia:a pharmacodynamic modeling-based approach in labouring parturients

Interactions of intrathecal drugs

Hong Kong

Yes

2005-04-27

Labour analgesia

Drug

Combined spinal epidural analgesia

30 min

Bupivacaine and fentanyl will given intrathecally in different dose combinations for labour analgesia. Pain scores will be assessed for 30 min

Inclusion criteria: Healthy ASA1-2 nulliparous single term parturients with cervical dilatation less than or equal to 5cm and baseline pain score of 50/100 or greater who request regional analgesia in labour.

Exclusion criteria: Parenteral opioid received in preceeding 2h, contradications to regional anaesthesia, allergy to bupivacaine or fentanyl, hypertension, known fetal abnormality.

18

50

Female

Interventional

Randomized

Dose comparison

Double-blind

Single group

2005-05-21

300

Recruiting

Pain score at 30 min

Determination of drug interactions

No

2013-04-24

ChiCTR-TRC-09000693

2010-05-04


Yes

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