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Trial History Detail on 2007-11-05

CUHK_CCT00122

2007-04-12

Retrospective

Research Grant Council Grant CUHK 4317/04

Nil

Adrian Wong

adrianwong@cuhk.edu.hk

email

Ka Sing Wong

ks-wong@cuhk.edu.hk

email

Effect of Multivitamins Supplementation on the Progression of Cerebral White Matter Changes and Cognitive Impairment in Chinese Stroke Patients with Moderate to Severe Leukoaraiosis

Yes

2004-05-04

Stroke with Moderate to Severe Leukoaraiosis

Drug

Daily folate 2mg + Vitamins B6 25mg + B12 500 microgram

2 years

Placebo

Inclusion Criteria All subjects presenting within 7 months of a stroke or TIA are eligible provided they agree to take study medication, be available for follow-up and provide written informed consent. Exclusion Criteria Taking vitamins on medical advice Independent self-medication with vitamin supplements containing B6, B12 or folate Taking methotrexate for any reason Pregnancy or women of child bearing potential who are at risk of pregnancy Limited (less than two years) life expectancy Auditory, visual, or language impairment, severe enough to prevent cognitive assessment Pacemaker or other contraindication to MRI scanning

Randomized

Placebo

Double-blind

Parallel

2004-05-10

100

Complete

Stroke (ischemic or hemorrhagic), myocardial infarction or death from any vascular cause

Transient ischemic attack, depression, dementia, unstable angina, revascularization procedures of the coronary, cerebral or peripheral circulations

No

2009-11-23


Yes

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