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Trial History Detail on 2018-10-19

CUHK_CCRB00628

2018-10-19

Prospective

NA

NA

NA

NA

Not Applicable

Miss Wong Sin Ting Janice

3/F, Hong Kong Eye Hospital, 147K, Argyle Street, Mongkok, Kowloon, Hong Kong

3943 5825

janicewong@cuhk.edu.hk

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong

Hong Kong

Dr. Leung Kai Shun Christopher

3/F, Hong Kong Eye Hospital, 147K, Argyle Street, Mongkok, Kowloon, Hong Kong

3943 5825

cksleung@cuhk.edu.hk

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong

Hong Kong

Identification of biomarkers for glaucoma in the tear fluid by next generation proteomic technology

Identification of biomarkers for glaucoma in the tear fluid by next generation proteomic technology

利用下一代蛋白質組學技術鑑定淚膜中青光眼的生物標誌物

Hong Kong

Yes

2018-05-04

Joint CUHK-NTEC Clinical Research Ethics Committee

2018.065

glaucoma

Procedure

A registered optometrist will collect tears sample from newly diagnosed glaucoma patients' both eyes. The procedure takes around 30 minutes. Ten to fifteen microliters tear will be obtained from the right lateral canthus of each subject using glass capillary tubes.

Ten to fifteen microliters tear will be obtained from the right lateral canthus of each subject using glass capillary tubes.

Ten to fifteen microliters tear will be obtained from the right lateral canthus of each subject using glass capillary tubes.

Around 30 minutes

Once

A registered optometrist will collect tears sample from normal control's both eyes. The procedure takes around 30 minutes. Ten to fifteen microliters tear will be obtained from the right lateral canthus of each subject using glass capillary tubes.

Ten to fifteen microliters tear will be obtained from the right lateral canthus of each subject using glass capillary tubes.

Ten to fifteen microliters tear will be obtained from the right lateral canthus of each subject using glass capillary tubes.

Around 30 minutes

Once

Control group subject inclusion criteria: 1. Chinese adults aged between 40-60

Control group subject inclusion criteria: 2. Spectacle corrected monocular VA: 0.2 logMAR or better after full correction

Control group subject inclusion criteria: 3. No contact lens wear

Control group subject inclusion criteria: 4. Free of ocular and systemic abnormalities e.g. cataract, diabetes mellitus (DM) Intraocular pressure (IOP): 21 mmHg or less in both eyes

Control group subject inclusion criteria: 5. Difference in IOP between two eyes: 3 mmHg or less

Control group subject inclusion criteria: 6. Able to give written consent

Newly diagnosed glaucoma group subject inclusion criteria: 1. Early onset of signs of primary open-angled glaucoma (POAG)

Newly diagnosed glaucoma group subject inclusion criteria: 2. Intraocular pressure (IOP): 22 mmHg or more in one or both eyes

Newly diagnosed glaucoma group subject inclusion criteria: 3. Sign of optic nerve abnormalities according to the classification of Mild or Early Stage Glaucoma in the Glaucoma ICD-10 quick reference guide of the American Academy of Ophthalmology (AAO)

Newly diagnosed glaucoma group subject inclusion criteria: 4. Free from other ocular and systemic diseases e.g. cataract, DM etc.

Newly diagnosed glaucoma group subject inclusion criteria: 5. Able to give written consent

1. Regular contact lens wear

2. DM, severe heart disease, history of stroke

3. Dry eye disease

4. Underwent LASIK surgery

40

60

Both Male and Female

Observational

Non-randomized

Not Applicable

Not Applicable

Not Applicable

4

To study the differential protein expressions of TGF-β-associated and ECM pathways in the tear fluid of normal control and newly diagnosed glaucoma patients by next generation proteomic approach, High Resolution Multiple Reaction Monitoring (MRM-HR).

2018-11-01

14 control subjects and 14 subjects with newly diagnosed glaucoma

Not Yet Recruiting

Differentially protein expressions

The total protein concentration will be determined using the 2-D Quant Kit (Amersham Biosciences) according to manufacturer’s instruction.

one

NA

NA

NA

No

2018-12-05

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