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Trial History Detail on 2009-11-19

CUHK_CCT00073

2005-09-13

Retrospective

HHSRF

HHSRF

Matthew Chan

Dept Anaesthesia and Intensive Care, CUHK

mtvchan@cuhk.edu.hk

Matthew Chan

Dept Anaesthesia and Intensive Care, CUHK

mtvchan@cuhk.edu.hk

Evaluation of Nitrous oxide In the Gas Mixture for Anesthesia: a randomized controlled Trial

The ENIGMA trial

Yes

2003-01-16

Quality of recovery

Drug

Nitrous oxide

Intraoperative peroid

Nitrous oxide administration

Inclusion Criteria: 1. Males and females, age 18 years and over 2. Planned general anesthesia for surgery that includes a skin incision and expected to exceed two hours, and the patient is expected to be in hospital for at least three days

Exclusion Criteria: 1. Endoscopic or radiological procedures 2. Cardiac surgery 3. Marked impairment of gas-exchange (requiring FiO2 > 0.3) 4. Thoracic surgery requiring one-lung ventilation (requiring FiO2 > 0.3) 5. Specific circumstances where N2O is contraindicated (eg. volvulus, pulmonary hypertension, raised intracranial pressure) 6. Lack of provision of N2O.

Randomized

Placebo

Double-blind

Parallel

2004-01-01

2000

Complete

Length of hospital stay

Perioperative complications Endothelial reactivity COMET assay

No

2007-09-15


Yes

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