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Trial History Detail on 2016-01-04

CUHK_CCRB00497

2016-01-04

Prospective

CRE-2015.477

Department of Obstetrics and Gunaecology, The Chinese University of Hong Kong

Department of Obstetrics and Gunaecology, The Chinese University of Hong Kong

NIl

Not Applicable

Tse Lai YIu/ Cosy Cheung

1/F Block F, Prince of Wales Hospital, Shating, NT

26321764

eristse@cuhk.edu.hk

CUHK

Hong Kong

Prof Li Tin Chiu

1/F Block F, Prince of Wales Hospital, Shating, NT

2632 2800

tinchiu.li@cuhk.edu.hk

CUHK

Hong Kong

Role of chronic endometritis in reproductive failure

Role of chronic endometritis in reproductive failure

慢性子宮內膜炎在生殖障礙中作用的研究

Role of chronic endometritis in reproductive failure

Hong Kong

Yes

2015-09-22

Joint CUHK-NTEC Clinical Research Ethics Committee

2015.477

Women with recurrent miscarriage, recurrent implantation failure, or with infertility undergoing IVF treatment .

Other

None

This project is an observational one. During the study, the procedure would be the same as per current practice,except saving two inner catheters instead of one.

NA

NA

NA

NA

NA

NA

NA

NA

NA

Age 20-40 years.

Women with recurrent miscarriage, recurrent implantation failure, or with infertility undergoing IVF treatment .

Uncorrected uterine anomalies, such as septate or bicornuate uterus, fibroids (submucous/intramural).

Intrauterine adhesions.

Adenomyosis.

Systematic disease that may cause subfertility, such as diabetes or systemic lupus erythematosus.

20

40

Female

Observational

Not Applicable

Not Applicable

Open label

Parallel

3

2016-01-15

300

Not Yet Recruiting

We will conduct a retrospective analysis of endometrial response to infection as measured by plasma cell count, uNK cell count and Toll like receptor expression in archived endometrial tissue specimen from several groups of women with reproductive failure. At the same time, a prospective study to ex

To examine markers of tissue response to infection including plasma cell count, uterine natural killer cell (uNK) count and Toll like receptor expression.

NA

Microbiome in uterine fluid at time of ET will be examined, as well as correlate findings with the various clinical outcomes of ET.

DNA extraction,PCR amplification,Next-generation sequencing

NA

No

2020-07-06

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