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Trial History Detail on 2016-04-05

CUHK_CCRB00484

2015-10-31

Prospective

CRE-2015.408

Nil

Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong

NIL

Not Applicable

ka Sing Lawrence Wong

9/F, Lui Che Woo Clinical Sciences Building
Department of Medicine & Therapeutics
Prince of Wales Hospital
Shatin, NT, Hong Kong

26323144

ks-wong@cuhk.edu.hk

CUHK

Hong Kong SAR, China

ka Sing Lawrence Wong

9/F, Lui Che Woo Clinical Sciences Building
Department of Medicine & Therapeutics
Prince of Wales Hospital
Shatin, NT, Hong Kong

26323144

ks-wong@cuhk.edu.hk

Division of Neurology, Prince of Wales Hospital

Hong Kong SAR, China

A Pilot Study of Dual Hemispheric Theta Burst Stimulation for Chronic Post-Stroke Aphasia

A Pilot Study of Dual Hemispheric Theta Burst Stimulation for Chronic Post-Stroke Aphasia

雙側經顱磁刺激對中風後慢性失語症康復的研究

Hong Kong SAR, China

Yes

2015-08-20

Hong Kong East Cluster Research Ethics Committee

2015.408

aphasia

stroke

Device

Transcranial Magnetic Stimulation

Theta Burst Stimulation

Dual Hemispheric Transcranial Magnetic Stimulation

about four minutes

once a day, totally ten times

No comparative treatment
Open label

NA

NA

NA

NA

aged 18 or above, right-handed, Cantonese native speaker

first-ever stroke (both ischemic stroke and hemorrhagic stroke) with onset time more than six months and left middle cerebral artery (LMCA) territory involved;

recordable motor evoked potential (MEP) in either hand

mild to moderate motor-dominant aphasia (National Institution of Health Stroke Scale (NIHSS) Part 9 = 1)

capable of undergoing language assessment (NIHSS Part 1a=0, 1b=0 or 1 and 1c= 0 or 1)

the patient or his/her legally acceptable representative is willing to provide written informed consent

personal history of epilepsy

metallic implants in any part of body

implanted cardiac pacemaker, defibrillator, medication pump or any other implanted electronics

severe skull fracture, serious head injury, history of brain or spinal cord surgery

brain tumor on CT/MRI

administration of drugs that potentially lower seizure threshold

active malignancy

severe co-existing systemic diseases, severe dementia or psychosis

inability to be followed up at regular interval

pregnancy or breast-feeding

pure word deafness

diagnosed dementia

clinical evidence of depression

clinical sign of hearing or visual impairment without aids

alcohol abuse and drug addiction

18

/

Both Male and Female

Interventional

Non-randomized

Uncontrolled

Open label

Single group

Other

Not a drug trail

2015-11-09

10

Not Yet Recruiting

changes in scores of language assessment

Cantonese version of Western Aphasia Battery

right after the intervention finished and two months later

changes in subscores of language assessment

Cantonese version of Western Aphasia Battery

right after the intervention finished and two months later

No

2017-04-25

ChiCTR-IPC-15007337

2015-10-31

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