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Trial History Detail on 2016-08-17

CUHK_CCT00457

2015-06-17

Prospective

CREC 2014.379-T

Hong Kong College of Family Physicians

Professor Regina Wing Shan SIT

N/A

Not Applicable

Wing Yin TAM

Room 04, 4/F, Lek Yuen Health Centre, 9 Lek Yuen Street, Shatin, N.T., Hong Kong

25039053

wingyintam@cuhk.edu.hk

The Chinese University of Hong Kong

Hong Kong

Professor Regina Wing Shan SIT

Room 17A, 4/F, Lek Yuen Health Centre, 9 Lek Yuen Street, Shatin, N.T., Hong Kong

25039053

reginasit@cuhk.edu.hk

Division of Family Medicine and Primary Health Care, The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong

Hong Kong

Effectiveness of patella mobilization therapy versus usual care in knee osteoarthritis: a pragmatic, randomized clinical trial

Effectiveness of patella mobilization therapy versus usual care in knee osteoarthritis: a pragmatic, randomized clinical trial

膝關節手法治療對退化性膝關節炎的效用

N/A

Hong Kong

Yes

2014-08-04

Joint CUHK-NTEC Clinical Research Ethics Committee

2014-379T

knee osteoarthritis

Procedure

Patella mobilization therapy

N/A

N/A

16 weeks

Every 8 weeks at week 0, 8, 16

Usual care

N.A

N/A

N/A

N/A

1) Age ≥ 45 to ≤ 75 years old
2) Diagnosis of knee OA based on clinical criteria as defined by the American Rheumatology Association
3) Have experienced moderate to severe knee pain for at least 3 months, defined as a score of 3 or more (0-6 ordinal response scale) on the question “What is the average level of your left/right knee pain?”
4) Involvement of anterior knee compartment and exhibit 2 of the following criteria on initial assessment: pain on direct compression of the patella against the femoral condyles with the knee in full extension, tenderness on palpation of the posterior surface of the patella, pain on resisted knee extension, and pain with isometric quadriceps contraction against suprapatellar resistance with the knee in slight flexion

1) Previous operation either open or arthroscopic, on the referring knee
2) Body mass index ≥ 35 kg/m2
3) Any knee injections within 1 month
4) Inflammatory or post-infectious knee arthritis
5) Daily use of opioid medication
6) Co-morbidity severe enough to prevent participation in the study protocol like attendance at scheduled appointments
7) Fixed flexion deformity >5 degree and varus and valgus deformity > 15 degree made manual mobilization of the patella impossible.

45

75

Both Male and Female

Interventional

Randomized

1:1 randomization

Active

Open label

Parallel

2

2015-06-30

208

Recruiting

The composite Western Ontario McMaster University Osteoarthritis Index (WOMAC)assessed at week 0 and week 24.

1) A visual analogue score (0-100mm) to assess knee pain of each symptomatic knee at week 0 and 24.
2) Knee flexion range at week 0 and week 24
3) 30 second chair stand performance test at week 0 and 24
4) timed up and go test at week 0 and 24.
5) 40 m fast-paced walk test at week 0 and 24
6) Compliance of the home based medial thigh exercise will be assessed by a 7 day recall on the number of days in the exercise participations at week 8,16 and 24.
7) Type and frequency of analgesics use will be assessed by pill counting in the past 7 days. It will be done at week 0,8,16 and 24 weeks for both groups
8)EuroQuol-5 at week 0 and 24 weeks
9) Standford Expectancy questionnaire (SAQ) at week 0
10) International Physical Activity Questionnaire (IPAQ) at week 0

No

2017-07-31

ChiCTR-IPC-15006618 

2015-06-17

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