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Trial History Detail on 2015-08-24

CUHK_CCT00424

2014-07-23

Prospective

KW/FR-13-023(67-05)

SADS HONG KONG FOUNDATION

Department of Medicine & Geriatrics, Princess Margaret Hospital

Pathology Department & Department of Paediatrics, Princess Margaret Hospital
Forensic Pathology Service, Department of Health

Dr. Ngai Shing MOK

Princess Margaret Hospital, Lai Chi Kok, Kowloon, Hong Kong

(852) 64610145

mokns@ha.org.hk

Department of Medicines & Geriatrics, Princess Margaret Hospital

Dr. Ngai Shing MOK

Princess Margaret Hospital, Lai Chi Kook, Kowloon, Hong Kong

(852) 64610145

mokns@ha.org.hk

Department of Medicine & Geriatrics, Princess Margaret Hospital

Sudden Arrhythmia Death Syndromes in Young Victims of Sudden Cardiac Death in Hong Kong Identified by Clinical or Molecular Autopsy of Victims and Clinical Evaluation of Their First Degree Relatives (SADS-HK Study)

Sudden Arrhythmia Death Syndromes in Young Victims of Sudden Cardiac Death in Hong Kong Identified by Clinical or Molecular Autopsy of Victims and Clinical Evaluation of Their First Degree Relatives (SADS-HK Study)

突發心律失常死亡綜合症臨床檢驗及基因測試研究(SADS - HK研究)

SADS-HK Study

Hong Kong

Yes

2013-11-18

Sudden Arrhythmia Death Syndromes

Other

Nil Intervention

Not Applicable

Not Applicable

Not Applicable

Index SCD Victims
1. Age 5 to 40 years
2. Death 1 hour after onset of symptoms or within 24 hours of the victim being seen alive
3. Negative autopsy or autopsy shows evidence of either hypertrophic or arrhythmogenic right ventricular cardiomyopathy
4. Negative toxicological screening
5. Informed consent obtained from their next-of-kin for a molecular autopsy in the study

Relatives of index SCD Victim
 All first-degree relatives who consent to undergo the clinical and genetic evaluation as described in this study protocol

Index SCD Victim
1. SCD victim with genetically proven SADS


Relatives of index SCD Victim
1. Pregnant women
2. Mentally or cognitively disabled to give informed consent
3. Unable to attend assessment clinic or clinical evaluation in PMH
4. < 5 years old

5 years old

40 years (SD vicitims), no age limit for relatives

Both Male and Female

Observational

Not Applicable

Not Applicable

Not Applicable

Not Applicable

2014-08-06

160

Unknown

Prevalence and types of SADS among the young SCD families in the study population identified by clinical and molecular autopsy of SCD victims and/ clinical and targeted genetic evaluation of their first-degree relatives

1. Genotypes of SADS victims in the study population
2. Number of young SUD families identified with SADS by molecular autopsy
3. Number of young SUD families identified with SADS by clinical evaluation of first-degree relatives
4. Number of young SUD families identified with SADS by a combined approach
5. Pattern of inheritance of SADS and their clinical characteristics among young SUD familie

No

2015-08-24

ChiCTR-OCS-14005008 

2014-07-25


Yes

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