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Trial History Detail on 2015-05-13

CUHK_CCT00406

2014-04-11

Prospective

CRE-2014.108

Pending RGC grant approval

Division of Cardiology
Department of Medicine and Therapeutics
The Chinese University of Hong Kong

N/A

Xue Ting WANG

Heart center 10/F, Department of medicine and Therapeutics,Clinical Science Building Prince of Wales Hospital,Shatin,Hong Kong

2632 1752

xueting@cuhk.edu.hk

CUHK

Prof.Alex Pui Wai LEE

9/F,Department of medicine and Therapeutics,Chinical Science Building Prince of Wales Hospital,Shatin,Hong Kong

2632 1299

alexpwlee@cuhk.edu.hk

CUHK


Dynamic quantification of ventriculo-annular motion with real-time 3D transesophageal echocardiography in mitral valve prolapse: Is systolic annular deepening important for the pathogenesis of mitral regurgitation?



Dynamic quantification of ventriculo-annular motion with real-time 3D transesophageal echocardiography in mitral valve prolapse: Is systolic annular deepening important for the pathogenesis of mitral regurgitation?

實時三維經食道超聲二尖瓣脫垂的動態定量:瓣環鞍形深化是否二尖瓣關閉不全的重要發病機制?

Mitral annulus dynamics 3D echo study

Hong Kong CHINA

Yes

2014-03-04

Mitral regurgitation

Other

N/A

N/A

N/A

N/A

1. MVP which is defined echocardiographically as more than 2mm displacement of the mitral leaflets into the left atrium beyond the annulus plane in parasternal long-axis view during systole, and
2. Clinical indication for TEE including evaluation of regurgitation severity, assessment of mitral valve repairability, preoperative evaluation, non-diagnostic transthoracic images, exclusion of endocarditis, and evaluation of cardiac source of embolic event.
- The proximal isovelocity surface area method will be used to quantify the effective regurgitant orifice (ERO) (32), with flow constraint corrected for the angle with the adjacent walls in cases where the regurgitation convergence is eccentric. Patients will be divided into 2 groups according to MR severity. The MVP-MR+ group with MR ≥3+ (ERO ≥0.3cm^2) and the MVP-MR- group with MR≤2+ (ERO ≤0.29 cm^2). Ruptured chordae tendinae and flail leaflet will be diagnosed by combined information obtained by 2D/3D echocardiography as previously described (16).
- Normal reference group: Patients who are referred for TEE and found to have no underlying cardiac abnormality or rhythm disturbance will be recruited.
- Non-prolapse organic MR group: Patients who have moderate or severe organic MR due to non-prolapse pathology as a reference group to ascertain any abnormality in ventriculo-annular interaction is not secondary to MR per se.

Mitral stenosis
-Aortic valve disease
-Congenital or pericardial diseases
-Endocarditis
-Cardiomyopathy
-Pregnancy
-Age<18y
-Contraindications to TEE

18

999

Both Male and Female

Observational

Randomized

Historical control

Open label

Parallel

2015-01-01

150

Unknown

Early systolic rate of change of MA geometry
Single time point at clinical TEE examination

N/A

No

2015-05-13

ChiCTR-TRC-14004749 

2014-06-05


Yes

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