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Trial History Detail on 2015-04-28

CUHK_CCT00399

2014-03-27

Prospective

CRE 2013.644-T

The Chinese University of Hong Kong

Dr KW Cheung

Prof. Kevin KW Ho

JoJo Kwok

Department of Orthopaedics and Traumatoloy, Prince of Wales Hospital, Shatin, Hong Kong

26326553

jojokwok@cuhk.edu.hk

Department of Orthopaedics and Traumatoloy, The Chinese University of Hong Kong

Dr KW Cheung

Department of Orthopaedics and Traumatoloy, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT Hong Kong, SAR

26321817

kwcheung@ort.cuhk.edu.hk

Department of Orthopaedics and Traumatoloy, Prince of Wales Hospital

Intra-articular VS Intravenous Tranexamic Acid in Total Knee Arthroplasty – A Randomized Controlled Trial Comparing Effectiveness and Safety

Intra-articular VS Intravenous Tranexamic Acid in Total Knee Arthroplasty

臨床研究 –「全膝關節置換手術:止血劑的成效與應用」

Intra-articular VS Intravenous Tranexamic Acid in Total Knee Arthroplasty

HKSAR

Yes

2014-01-16

Knee Osteoarthritis

Drug

Tranexamic acid

During the operation

To compare the blood-saving effects and risks of developing symptomatic thromboembolic events after total knee arthroplasty by using intra-articular and intravenous tranexamic acid

Inclusive criteria are subjects with degenerative osteoarthritis of knee joints, who are scheduled for TKA with posterior stabilized total knee prosthesis.

Exclusion criteria are patients with pre-operative anemia with haemoglobin level less than 12 g/dL (reference of PWH lab), known allergy to TNA, deep vein thrombosis, pulmonary embolism, ischemic stroke, those on anticoagulant drugs including warfarin and Plavix, or those undergo TKA under epidural anesthesia, those with renal impairment(with creatinine level >200) and inflammatory arthritic patient.

18

100

Both Male and Female

Interventional

Randomized

Dose comparison

Single-blind

Parallel

2014-03-28

150

Unknown

Blood loss after operation, based on the change in haemoglobin level, drain output and wound discharge at baseline and post-operation day 5; any symptomatic thromboembolic events after operation at post-operation day 5

Length of stay in hospital

No

2015-07-30

ChiCTR-TRC-14004440 

2014-03-29


Yes

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