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Trial Detail

CUHK_CCT00394

2014-02-05

Prospective

CRE-2013.666-T

The Chinese University of Hong Kong

Department of Anaesthesia & Intensive Care, The Chinese University of Hong Kong

N/A

Simon Chan

Department of Anaesthesia & Intensive Care, Prince of Wales Hospital, Shatin, Hong Kong

(852)2632 2734

simonkcchan@cuhk.edu.hk

Department of Anaesthesia & Intensive Care, Prince of Wales Hospital

Ms Winnie Samy

Department of Anaesthesia & Intensive Care, Prince of Wales Hospital, Shatin, Hong Kong

(852)2632 2735

wsamy@cuhk.edu.hk

Department of Anaesthesia & Intensive Care, Prince of Wales Hospital

A randomized-control multi-centres study on the safety & effectiveness of peri-operative transfusion trigger score (POTTS)

A randomized-control multi-centres study on the safety & effectiveness of peri-operative transfusion trigger score (POTTS)

圍手術期輸血指征評分(Peri-Operative Transfusion Trigger Score, POTTS)安全性與有效性的多中心,隨機,對照臨床研究

RCT on POTTS

Hong Kong

Yes

2014-01-27

Elective surgery with potential massive blood loss requiring blood transfusion

Other

Decision on blood transfusion

The decision on blood transfusion will be in accordance on the POTTS scoring system based on: inotrope requirement, oxygen requirement, body temperature and history of coronary artery disease.

Intra-operative and post-operative period.

Elective surgical patients will be randomized to 3 groups:
1. transfusion to keep Hb > 10g/dL ,
2. transfusion based on clinicians' discretion when Hb between 7-10g/dL; and
3. POTTS group.

1. Age≥14 weeks old
2. Live in an area of altitude < 2500 m most of the time
3. Estimated intraoperative blood loss >1000ml, or > 20% of total blood volume

1 Emergency surgery
2 Patients with physical status of ASA class V or above
3 Patients with known severe haematological disorders
4 Patients with known haemaglobinopathy
5 Acute hypervolemic haemodilution is planned.
6 Patients with known metastatic cancer or more than one neoplasm concurrently.
7 Other conditions that may preclude the patients from the study, such as language barrier, psychiatric disorders, unable to attend research center for follow up.
8 Patients who enrolled to another research study or are taking experimental medication in last 3 months prior to this study.
9 Not suitable for the study, after assessment by the investigators

14 weeks old

nil

Both Male and Female

Interventional

Randomized

Not Applicable

Open label

Not Applicable

2014-02-20

20

Unknown

1 Incidence of patients required blood transfusion and the unit number of blood transfused.
2 Mortality rate and incidence of serious complications.
3 Five-year in remission survival rate after hospital discharge and overall survival rate.

1 Intensive Care Unit (ICU) admission rate and ICU length of stay (LOS)
2 Post-operative Hb level
3 Surgical wound complication rate
4 Hospital length of stay
5 Transfusion-related cost and hospital admission cost
6 Post-operative quality of life

No

2015-12-27

ChiCTR-TRC-14004478 

2014-04-10

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