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Trial History Detail on 2016-03-24

CUHK_CCT00383

2013-12-17

Prospective

Nil

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong

Nil

Not Applicable

Ms. Jennifer Tsoi

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, 3/F, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon

3943 5869

jennifertsoi@cuhk.edu.hk

The Chinese University of Hong Kong

Hong Kong

Dr. Yam Cheuk Sing Jason

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, 3/F, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon

39435892

yamcheuksing@gmail.com

The Chinese University of Hong Kong

Hong Kong

Evaluation of different concentration of low dose topical atropine in retarding myopia progression

Evaluation of different concentration of low dose topical atropine in retarding myopia progression

不同濃度阿托品眼藥水在近視加深控制之研究

Low dose atropine for myopia progression study

Hong Kong

Yes

2013-11-19

Kowloon Central Cluster REC / Kowloon East Cluster REC

KC/KE-13-0182/FR-2

Myopia

Drug

Atropine

Eyedrop

Group 1 will use 0.1% atropine eyedrop daily, Group 2 will use 0.05% atropine eyedrop daily, Group 3 will use 0.025% atropine eyedrop daily. Group 4 will use 0.01% atropine eyedrop once daily. Group 5 will receive the placebo eyedrop.

2 years

Once Daily

Normal saline(Placebo)

Eyedrop

0.9%

2 years

Once Daily

 Age 4 to 12
 Myopia : SE -1 to -10 D
 Astigmatism: < 2.5 D
 Anisometropia : < 2.0 D
 History of myopia progression > 0.5 D for Both eyes in one year
 Informed parental consent

 Ophthalmic diseases other than refractive errors
 Previous use of treatment of atropine
 Allergy or intolerance to atropine
 Inability to attend regular follow up assessment

4

12

Both Male and Female

Interventional

Randomized

Subjects will be assigned to 5 arms

Placebo

Double-blind

Parallel

4

2014-01-02

520

Recruiting

-Change in spherical equivalent refraction (cycloplegic refraction)
-Change in axial length

-Safety variable: Best corrected visual acuity, pupil size, intraocular pressure

No

2021-07-07

ChiCTR-TRC-13004032

2013-12-24

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