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Trial History Detail on 2012-10-22

CUHK_CCT00320

2012-05-17

Prospective

Nil

Nil

Nil

Nil

Alex Pui Wai LEE

Division of Cardiology, Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong

852-2632 3140

alexpwlee@cuhk.edu.hk

Department of Medicine & Therapeutics, The Chinese Univerity of Hong Kong

Qing SHANG

Division of Cardiology, Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong

852-2632 3840

qingshang@cuhk.edu.hk

Department of Medicine & Therapeutics, The Chinese Univerity of Hong Kong

Cardiovascular Reserve in Patients with Systemic Autoimmune Diseases

Cardiovascular Reserve in Patients with Systemic Autoimmune Diseases

Nil

Hong Kong SAR, China

Yes

2012-03-21

Rheumatic diseases

Other

None

N/A

N/A

N/A

Patients with SLE or PsA, Control subjects who are considered to have a low probability of coronary artery disease on clinical grounds and have a normal exercise stress echocardiogram.

Exclusion criteria are uncontrolled severe hypertension (Resting systolic blood pressure is 180mmHg or greater or diastolic blood pressure is 120mmHg or higher), significant atrial or ventricular arrhythmia, significant valvular diseases (>moderate severity), significant coronary artery disease, prior history of myocardial infarction, impaired LV systolic function (ejection fraction<50%, or any regional wall motion abnormality), pericardial disease and unable to exercise.

18 years

N/A

Both Male and Female

Observational

Non-randomized

Not Applicable

Not Applicable

Parallel

2012-07-04

150

Not Yet Recruiting

1. Changes in resting cardiac function and functional reserve during exercise in 3-dimensional planes
2. Increased arterial stiffness in resting and impaired vascular reserve during exercise
3. Association among early cardiovascular dysfunction, impaired functional reserve during exercise and biomarkers

N/A

No

2014-11-24


Yes

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