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Trial History Detail on 2015-01-08

CUHK_CCT00313

2012-02-03

Prospective

Nil

Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong

Nil

Nil

TSE Lai Yiu

1/F, Block F, Department of Obstetrics &Gynaecology, Prince of Wales Hospital

26321764

eristse@cuhk.edu.hk

Nil

Dr. Cathy Hoi Sze CHUNG

1/F, Block F, Department of Obstetrics &Gynaecology, Prince of Wales Hospital

2632 2585

cathychung@cuhk.edu.hk

Nil

Ovarian response in poor ovarian responder: a randomized controlled trial on the effect of mid-follicular phase recombinant luteinizing hormone versus low dose urinary human chorionic gonadotrophin supplement on in-vitro fertilization cycles.

: Ovarian response in poor ovarian responder: a randomized controlled trial on the effect of mid-follicular phase recombinant luteinizing hormone versus low dose urinary human chorionic gonadotrophin supplement on in-vitro fertilization cycles.

Nil

Hong Kong

Yes

2011-11-08

women undergoing IVF-ET cycles

Drug

Subcutaneous injection of rLH or uhCG injection

Subcutaneous injection of rLH or uhCG injection since day 6 of ovarian stimulation in IVF cycles un

Nil

1. History of 2 episodes of poor ovarian response (≤3 mature follicles on ovulatory dose of hCG or ≤3 mature oocytes retrieved) despite maximal stimulation; or
2. Patients fulfill two out of three of the following features:
I. Age ≥40 or any other risk factors
i. History of ovarian surgery
ii. History of salpingectomy
iii. History of chemotherapy
iv. Present of ovarian endometrioma
II. Previous poor ovarian response (≤3 mature follicles on ovulatory dose of hCG or ≤3 mature oocytes retrieved)
III. Abnormal ovarian reserve test
i. Follicle stimulating hormone(FSH) 10 mIU/L; or
ii. Antral follicle count (AFC) ≤7 follicules; or
iii. Anti-Müllerian hormone (AMH) ≤1.1 ng/ml

1. Body mass index≥30kg/m2
2. Absent of one ovary
3. History of polycystic ovarian disease
4. Present of uterine abnormalities
5. Present of endocrine/metabolic/autoimmune disease
6. Incompetence or refuse for informed consent

18

45

Female

Interventional

Randomized

Active

Double-blind

Parallel

2012-03-01

60

Recruiting

Number of mature oocytes retrieved on day of oocyte pick-up

• Clinical pregnancy rates (defined as presence of intrauterine gestational sac with cardiac activity)
• Implantation rates (defined as number of gestational sacs / transferred embryos)
• Ongoing pregnancy rates (defined as pregnancy more than 12 weeks of gestation)
• Live birth rates (defined as delivery of live baby more than 24 weeks of gestation)

No

2015-07-07

ChiCTR-TRC-12002072

2012-04-04


Yes

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