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Trial History Detail on 2012-12-10

CUHK_CCT00296

2011-08-12

Prospective

2011/08/12

Department funded

Dept. of Anesthesia and Intensive Care

N/A

Zhu Fang

R04C06, Dept. of Anesthesia and Intensive Care, 4/F Mainblock and Trauma Centre, Prince of Wales Hospital, the Chinese university of Hong Kong, Shatin, NT, HKSAR

2632 1912(office)

yqnoangel@gmail.com

Dept. of Anesthesia and Intensive Care, CUHK

Zhu Fang

R04C06, Dept. of Anesthesia and Intensive Care, 4/F Mainblock and Trauma Centre, Prince of Wales Hospital, the Chinese university of Hong Kong, Shatin, NT, HKSAR

2632 1912(office)

yqnoangel@gmail.com

Dept. of Anesthesia and Intensive Care, CUHK

Prospective Randomized Controlled Trial Comparing Adaptive-support Ventilation ,INTELLiVENT-ASV and physician-led weaning on weaning patients cardiac surgery patients.

Prospective Randomized Controlled Trial Comparing Adaptive-support Ventilation ,INTELLiVENT-ASV and physician-led weaning after Cardiac Surgery

Early extubation after cardiac surgery

Hong Kong SAR, China

Yes

2012-07-05

coronary artery disease

Other

Weaning protocols

INTELLiVENT-ASV ventilation mode,
Adaptive-support ventilation mode

During intensive care unit stay

Physician-led weaning

Haemodynamically stable patients aged over 18 years, receiving mechanical ventilation support after elective coronary arterial bypass grafting will be consecutively included. Written informed consent will be obtained from each patient before surgery.

Preoperative exclusion criteria: patients older than 80 years or younger than 18 years, acute or chronic obstructive pulmonary disease (primary indication for ventilation), and concomitant valvular and/or aortic surgeries, major organ failure (liver disease, renal failure), history of seizure or stoke are excluded preoperatively.

Postoperative exclusion criteria: Severe early postoperative haemorrhage (chest tube drainage >500 ml/h), surgical complications needing reoperation, myocardial ischemia (ST-segment depression) lasting more than 30 min, postoperative cardiac failure necessitating high-dose inotropes or intra aortic balloon pump; refractory hypoxemia (ratio of arterial oxygen tension [PaO2] to fraction of inspired oxygen [FIO2] < 150 mmHg)

18

80

Both Male and Female

Interventional

Randomized

Active

Single-blind

Parallel

2012-10-01

90

Recruiting

Duration of mechanical ventilation during intensive care unit stay, Frequency of manual setting during intensive care unit stay,
Frequency of alarms during intensive care unit stay

Hospital length of stay during hostipal stay; Reintubation rate during intensive care unit stay;
Tidal volume within 10 minutes after weaning; Respiratory ratr within 10 minutes after weaning

No

2015-01-14

ChiCTR-TRC-11001505

2011-09-09


Yes

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