CCRB Logo

Trial History Detail on 2007-11-12

CUHK_CCT00035

2005-09-07

Retrospective

Sanofi-Synthelabo H.K. Ltd

Department of Medicine & Therapeutics, The Chinese University of Hong Kong

N/A

Skiva Chan

Department of Medicine & Therapeutics, The Chinese University of Hong Kong

2646-3200

Prof. John E. Sanderson

Professor of Clinical Cardiology, University of Birmingham

j.e.sanderson@bham.ac.uk

Treatment of Diastolic Heart Failure: The Role of Blockade of the Renin-Angiotensin System. A Comparison of Diuretics with an Angiotensin Converting Enzyme Inhibitor, Angiotensin Receptor Blockade or Diuretics Alone

Yes

1998-05-01

Heart and Blood Vessel Diseases

Drug

Diastolic Failure Patients

1 year

Ramipril + Diuretics vs. Irbesartan +Diuretics vs. Diuretics alone

Inclusion:1. Signed informed consent 2. Age >18 yrs 3. history of heart failure for 2 months prio to screening 4. NYHA Functional Class II-IV 5. LV EF >45% by ECHO or a radionucleotide technique 6. Therapy with diuretics with stable dose >14 days prior to screening. Exclusion: 1. NHYA class I 2. Inability to answer the QOL questionnaire 3. Myocardial infarction within 3 months, 4. unstable angina within 1 month 5. Significant cardiac valvular heart disease 6. Hypotension SBP <90 mmHg 7. uncontrolled hypertension(DBP>105 ors SBP> 200 mmHg) 8. uncontrolled serious cardiac arrhythmias associated with a ventricular rate >100 bpm at study entry 9. concurrent therapy with CCB, Betablocker, ACEI, AII or positive inotropic agents other than digoxin for control of AF

Randomized

Uncontrolled

Open label

Parallel

1999-07-13

450

Complete

1. Number of hospital admissions for heart failure or mortality 2. Quality of life assessed by the Minnesota Quality of life Questionnaire 3. In ambulatory patients the exercise duration assesssed by 6 min corridor walk test

The incidence of side-effects, effect on levels of natriuretic peptides, effect on doppler-echocardiographic derived measurements of left ventricular diastolic function.

No

2009-11-25


Yes

Type Access Document Published On  
No documents yet.
  • Page 1 of 1.