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Trial History Detail on 2011-02-08

CUHK_CCT00029

2005-09-13

Retrospective

/

CUHK

CUHK

N/A

Cheng Yuk Lun

11 Chuen On Road, Tai Po, N.T. Hong Kong, China

852-2689 3023

chengyl1@ha.org.hk

Dept. of Medicine, Alice Ho Miu Ling Nethersole Hospital

Cheng Yuk Lun

11 Chuen On Road, Tai Po, N.T. Hong Kong, China

852-2689 3023

chengyl1@ha.org.hk

Dept. of Medicine, Alice Ho Miu Ling Nethersole Hospital

Effect of Haemdialysis Membrane Permeability on Inflammatory Indices and Arterial Stiffness: A Comparison between 2 Dialyzers Composing of Identical Material but with Different Flux Characterics.

Effect of Haemdialysis Membrane Permeability on Inflammatory Indices and Arterial Stiffness: A Comparison between 2 Dialyzers Composing of Identical Material but with Different Flux Characterics.

Effect of dialysis flux on inflammatory indices and arterial stiffness

Hong Kong, China

Yes

2004-12-14

Heart and Blood Vessel Diseases

Device

The recruited patients will be put on 24 weeks of haemodialysis with high-flux dialyzer. Patients will otherwise be dialyzed with their usual prescriptions.

24 weeks

The recruited patients will be put on 24 weeks of haemodialysis with low-flux dialyzer.

1. Anuric (urine output < 100 ml/day). 2. Age between 18 and 75 years old. 3. On hemodialysis treatment with bicarbonate dialysate, for at least 3 months. 4. On a dialyzer reuse program using polysulfone dialyzer for at least 3 months. 5. Stable with no change in dialysis prescription for at least 3 months preceding enrolment. 6. Vascular access functioning properly. 7. Informed consent.

1. Contraindication for dialyzer reuse. 2. Active infection, inflammatory disease, ongoing malignancy or active phase immune disease. 3. Patient with immunosuppressive medication. 4. Recently measured C-reactive protein level > 50 mg/L. 5. Predictable survival < 1 year. 6. Planned renal transplantation within the 1-year study period.

18

75

Both Male and Female

Interventional

Randomized

Active

Open label

Crossover

2005-03-01

40

Complete

Comparing the arterial pulse wave velocity and the inflammatory indices between the 2 groups.

Comparing the biochemical markers between the 2 groups.

No

2009-11-27

ChiCTR-TRC-09000658

2010-05-04


Yes

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