CUHK_CCT00029
2005-09-13
Retrospective
CUHK
CUHK
N/A
Cheng Yuk Lun
email chengyl1@ha.org.hk
Cheng Yuk Lun
email chengyl1@ha.org.hk
Effect of Haemdialysis Membrane Permeability on Inflammatory Indices and Arterial Stiffness: A Comparison between 2 Dialyzers Composing of Identical Material but with Different Flux Characterics.
Effect of dialysis flux on inflammatory indices and arterial stiffness
Yes
2004-12-14
Heart and Blood Vessel Diseases
Device
The recruited patients will be put on 24 weeks of haemodialysis with high-flux dialyzer. Patients will otherwise be dialyzed with their usual prescriptions.
24 weeks
The recruited patients will be put on 24 weeks of haemodialysis with low-flux dialyzer.
Inclusion criteria: 1. Anuric (urine output < 100 ml/day). 2. Age between 18 and 75 years old. 3. On hemodialysis treatment with bicarbonate dialysate, for at least 3 months. 4. On a dialyzer reuse program using polysulfone dialyzer for at least 3 months. 5. Stable with no change in dialysis prescription for at least 3 months preceding enrolment. 6. Vascular access functioning properly. 7. Informed consent.
Exclusion criteria: 1. Contraindication for dialyzer reuse. 2. Active infection, inflammatory disease, ongoing malignancy or active phase immune disease. 3. Patient with immunosuppressive medication. 4. Recently measured C-reactive protein level > 50 mg/L. 5. Predictable survival < 1 year. 6. Planned renal transplantation within the 1-year study period.
Randomized
Active
Open label
Crossover
2005-03-01
40
Recruiting
Comparing the arterial pulse wave velocity and the inflammatory indices between the 2 groups.
Comparing the biochemical markers between the 2 groups.
2009-11-27
Yes
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