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Trial History Detail on 2009-11-19

CUHK_CCT00029

2005-09-13

Retrospective

CUHK

CUHK

N/A

Cheng Yuk Lun

email chengyl1@ha.org.hk

Cheng Yuk Lun

email chengyl1@ha.org.hk

Effect of Haemdialysis Membrane Permeability on Inflammatory Indices and Arterial Stiffness: A Comparison between 2 Dialyzers Composing of Identical Material but with Different Flux Characterics.

Effect of dialysis flux on inflammatory indices and arterial stiffness

Yes

2004-12-14

Heart and Blood Vessel Diseases

Device

The recruited patients will be put on 24 weeks of haemodialysis with high-flux dialyzer. Patients will otherwise be dialyzed with their usual prescriptions.

24 weeks

The recruited patients will be put on 24 weeks of haemodialysis with low-flux dialyzer.

Inclusion criteria: 1. Anuric (urine output < 100 ml/day). 2. Age between 18 and 75 years old. 3. On hemodialysis treatment with bicarbonate dialysate, for at least 3 months. 4. On a dialyzer reuse program using polysulfone dialyzer for at least 3 months. 5. Stable with no change in dialysis prescription for at least 3 months preceding enrolment. 6. Vascular access functioning properly. 7. Informed consent.

Exclusion criteria: 1. Contraindication for dialyzer reuse. 2. Active infection, inflammatory disease, ongoing malignancy or active phase immune disease. 3. Patient with immunosuppressive medication. 4. Recently measured C-reactive protein level > 50 mg/L. 5. Predictable survival < 1 year. 6. Planned renal transplantation within the 1-year study period.

Randomized

Active

Open label

Crossover

2005-03-01

40

Recruiting

Comparing the arterial pulse wave velocity and the inflammatory indices between the 2 groups.

Comparing the biochemical markers between the 2 groups.

No

2009-11-27


Yes

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