CUHK_CCT00170
2008-11-06
Prospective
ICM/CTS/08/346
Institute of Chinese Medicine
Department of Medicine & Therapeutics, CUHK
Institute of Chinese Medicine, CUHK Department of Chemical Pathology, CUHK Community and Family Medicine, CUHK
Winnie Lo (Research Nurse)
Institute of Chinese Medicine, CUHK
2252 8863
winnielo@cuhk.edu.hk
ICM, CUHK
Prof. Timothy Kwok (PI)
Department of Medicine & Therapeutics, Prince of Wales Hospital, CUHK
2632 3594
tkwok@cuhk.edu.hk
Medicine & Therapeutics, Prince of Wales Hospital, CUHK
A randomized placebo controlled trial of Alternative Herbal Medicine (Danshen/Gegen) in the prevention of atherosclerosis in postmenopausal women with Hypercholesterolemia
A randomized placebo controlled trial of Alternative Herbal Medicine (Danshen/Gegen) in the prevention of atherosclerosis in postmenopausal women with Hypercholesterolemia
Trial of Danshen/Gegen in postmenopausal women with hypercholesterolemia
Hong Kong
Yes
2008-10-21
Postmenopausal women with Hypercholesterolemia at risk of Atherosclerosis
Drug
Danshen/Gegen (Herbal Medicine)
52weeks
Placebo; 52 weeks
Inclusion Criteria: Women aged 45-65 years who had not had menstruation for more than 12 months and with fasting serum LDL ≥ 3.5mmol/L and < 4.9mmol/L. Subjects with serum LDL >4.9 mmol/L will be advised to take statin as recommended by the US guideline, but will be allowed to participate in this trial if they so wish.
Exclusion Criteria: history of diabetes mellitus, hypertension, ischaemic heart disease, cerebrovascular disease, renal impairment, significant drug hypersensitivity, current smoking, hormonal replacement, lipid lowering drugs, blood pressure >140/90 mmHg on two separate occasions, fasting glucose > 7.0 mmol/L, creatinine >100µmol/L, triglyceride > 11.3 mmol/L, significant ischaemic ECG changes or angina symptom.
45
65
Female
Interventional
Randomized
Placebo
Double-blind
Parallel
2008-11-11
160
Recruiting
Carotid Intima-media thickness at 12 month
Serum LDL at 12 Month Serum triglyceride at 12 Month
2011-03-04
ChiCTR-TRC-09000727
2010-05-04
Yes
Nil
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