Automatic Retinal Image Analysis (ARIA) as a Screening Tool in the Community

Peer Reviewed Journal Publications (Relevant to ARIA only)

  • Lau A, Mok V, Lee J, Fan Y, Zeng J, Lam b, Wong A, Kwok C, Lai M, Zee B, “Retinal image analytics detects white matter hyperintensities in healthy adults”, Annals of Clinical and Translational Neurology, 15 November 2018,

paper heading


  • Zhuo Y, Yu H, Yang Z, Zee B, Lee J, Kuang L “Prediction Factors of Recurrent Stroke among Chinese Adults Using Retinal Vasculature Characteristics”, J Stroke Cerebrovasc Dis. 2017 Apr;26(4):679-685. doi: 10.1016/j.jstrokecerebrovasdis.2017.01.020. Epub 2017 Feb 21.

recurrent stroke


  • Zee B., Lee J., Li Q., Mok V., Kong A., Chiang L.K., Ng L., Zhuo Y., Yu H., Yang Z. “Stroke risk assessment for the community by automatic retinal image analysis using fundus photograph, Quality in Primary Care (2016) 24 (3): 114-124



  • Guo, V.Y., Chan, J.C.N., Chung, H., Ozaki, R., So, W., Luk, A., Lam, A., Lee, J., Zee, B.C.. Retinal Information is Independently Associated with Cardiovascular Disease in Patients with Type 2 diabetes (2016) Scientific Reports, 6, art. no. 19053; doi: 10.1038/srep19053.



  • Guo V., Cao B., Wu X., Lee, J., Zee B.C. Prospective Association between Diabetic Retinopathy and Cardiovascular Disease – A Systematic Review and Meta-analysis of Cohort Studies, Journal of Stroke and Cerebrovascular Diseases, 25 (7), July 2016, pp. 1688–1695



  • Chiang LK, Yau MKC, Kam CW, Ng LV, Zee BCY, “Epidemiological study of hypertensive retinopathy in the primary care setting: Retrospective cross-sectional review of retinal photographs”, (2016) Family Medicine and Community Health, 4 (4), pp. 13-21

Chiang paper

  • Lee J, Zee B, Li Q, “Detection of Neovascularization based on Fractal and Texture Analysis with Interaction Effects in Diabetic Retinopathy”, PLoS One. 2013 Dec 16;8(12):e75699. doi: 10.1371/journal.pone.007569



  • Lee J, Zee B, Li Q, “Segmentation and texture analysis with multimodel inference for the automatic detection of exudates in early diabetic retinopathy”, J. Biomedical Science and Engineering, 2013, 6, 298-307.



Conference Presentations (Relevant to ARIA only).

  1. A. Lau, V. Mok, B. Lam, A. Wong, J. Lee, M. Lai, B. Zee, “Automated retinal image analysis to detect white matter hyperintensities in stroke- and dementia-free healthy subjects – a cross-validation study”, European Stroke Organization Conference, 16-18 May 2018, Gothenburg, Sweden.
  2. Y. Wong, B. Lam, J. Lee, M. Lai, L. Au, A. Wong, B. Zee, V. Mok, Development of an automatic retinal image analysis (ARIA) for screening cerebral small vessel disease in the community, Journal of the Neurological Sciences, Volume 381, Supplement, 15 October 2017, Page 959, ISSN 0022-510X,
  3. Benny ZEE, Vincent MOK, Jack LEE, Yannie SOO, Maria LAI, Chloe KWOK, Mark CHONG, Pauline KWAN, Eugene LO, Adrian WONG, “White matter hyperintensities (WMH) estimated by automatic retinal images analysis (ARIA) for early detection of dementia”, Poster Presentation, Gordon Research Conference – Cognitive Dysfunction in Brain Diseases Meeting, 11-16 June 2-17, Chinese University of Hong Kong
  4. Benny ZEE, Vincent MOK, Jack LEE, Yannie SOO, Maria LAI, Chloe KWOK, Mark CHONG, Pauline KWAN, Eugene LO, Adrian WONG, “Association between risks of dementia and stroke based on white matter hyperintensities (WMH) estimated by automatic retinal images analysis (ARIA)”, Poster Presentation, International Alzheimer’s Disease Conference, 26-27 May 2017, Hong Kong Science and Technology Parks
  5. Lei Kuang, Benny Zee, Jack Lee, Eric Hui, Shuk-Yun Leung, Sum Lee, Rebecca Thomas, David Owens, Association and Predictive Model for Diabetic Neuropathy Using Retinal Image Characteristics, Control #2017-A-4144-Diabetes, American Diabetes Association’s 77th Scientific Sessions, June 9-13, 2017 in San Diego, California
  6. Lei Kuang, Benny Zee, Jack Lee, Eric Hui, Shuk-Yun Leung, Sum Lee, Rebecca Thomas, David Owens, Association between Retinal Vascular Structure and Diabetic Nephropathy, Control #2017-A-4190-Diabetes, American Diabetes Association’s 77th Scientific Sessions, June 9-13, 2017 in San Diego, California.
  7. Zee B., Mok V., Lee J., Lai M., Kwok C., Chong M., Kwan P., Lo E., Wong A. “Automatic Retinal Image Analysis As An Early Screening Tool For Risk Of Dementia In The Community”, BRAIN 2017 Conference and The 14th Asia Pacific Multidisciplinary Meeting for Nervous System Diseases, 6–7 January 2017
  8. Zee B, “A System Science Approach for Accessing Innovative Community-based eHealth Method: An example using Automatic Retinal Image Analysis (ARIA) for hypertension” in the Plenary Session 4 – Public Health Innovation and Informatics with a System Science Perspective, JCSPHPC 15th Anniversary Conference: International Conference on Innovation in Public Health Sciences, 23 – 25 September 2016
  9. Zee, B “Automatic Retinal Image Analysis for stroke risk estimation as a tool for health promotion in public health application”, in Parallel Session H – Frontier Technologies with Impacts in Public Health, JCSPHPC 15th Anniversary Conference, 23 – 25 September 2016
  10. Zee B, “Automatic retinal image analysis (ARIA) for stroke risk assessment in the community using fundus photographs”, Engineering Medical Innovation Summit: Medicine for the Future (EMedI Summit) 2016, Convention Centre 3 (Phase III), Hong Kong Science Park, 20-21 August 2016
  11. Zee B, “Innovation and Technology Advancement for Global Public Health in the eHealth Era”, Keynote Speaker for the 5th Annual Global Healthcare Conference (GHC 2016), Singapore, 18-19 July 2016
  12. Zee B, “Innovation and Technology Advancement for Health Care System in the eHealth Era”, Asia Pacific Electronic Health Records Conference 2016, Hong Kong Convention Centre, 6 July, 2016
  13. Kuang L and Zee B. Oral presentation: Early Detection of Diabetic Neuropathy using Retinal Image, SMDM: Asia-Pacific Conference, Hong Kong 2016
  14. Kuang L and Zee B. Poster: Association between Vascular risk factor, Retinopathy, Renal Insufficiency and Diabetic peripheral neuropathy in U.S Adults with Pre-diabetes and Diabetes using National Health and Nutrition Examination Study (NHANES) 1999-2004. HKCCM Annual Scientific Meeting (ASM), Hong Kong 2015
  15. Guo, Yawei; Zee Chung Ying Benny; Chung Hau Yee; Osaki Risa; So Wing Yee; Luk Andrea; Augustine Lam; Lee Jock Wai And Chan Chung Ngor Juliana. “Retinal Biomarkers as a Potential Tool for the Detection of Coronary Heart Disease in Patients with Type 2 Diabetes “. Paper presented in the American Diabetes Association scientific sessions, organized by American Diabetes Association. San Francisco, United States of America, 2014.06.11.
  16. Zee B, “Innovative Retinal imaging analysis for diabetic patients”, The HK – Swiss Diabetics Scientific Seminar, Grand Hyatt Hotel, Wan Chai 10-11 Oct 2012.
  17. Zee B, “Medical Device Development by Biostatistician: A Change in Research Mind Set”, Keynote Speaker to Biomedical Engineering International Conference 2012 (BME2012), Hong Kong Productivity Council, 7 Dec 2012


AWARDS (Relevant to ARIA)

  1. Hong Kong Smart City Summit cum Smart City Awards 2018 for Health View Bioanalytic Limited “Outstanding Assessment of Health Data Analysis Program” 11 June 2018 (香港智慧城市峰會暨智慧城市大獎2018 “傑出評估健康之數據分析方案”)
  2. Shenzhen Municipal “Science and Technology Project Award 2016 (Advanced Individual)” 深圳市級科技項目獎 (先進個人) – presented by Shenzhen Science and Technology Innovation Committee (深圳市科技創新委員會) on April 2017
  3. “Best Innovative Award” and “Best Protocol Award”, CUHK Entrepreneur Day 2017 Competition, 12 May 2017. 中大創業大賽2017 – 傑出創新創意獎,傑出方案獎
  4. “Technological Achievement Award” – 2016 Hong Kong Awards for Industries (HKAI)
  5. Innovation Forum – Imagine IF 2016, Top 50
  6. Talent Unleashed “Best Startup – Social Impact”, Top 3 Finalist of Asia Pacific Region, Melbourne, Australia 21 July 2016.
  7. 5th Bank of China, Hong Kong Federation of Innovative Technologies and Manufacturing Industries (FITMI) “Technology Start-up” Merit Award, 10 Dec 2015
  8. Vice Chancellor Cup for Entrepreneurship (VCCE) competition – Topic: Automatic Retinal Image Analysis. Champion on February 2011 , with Li Qing (PhD student in SPHPC) and a group of MBA students
  9. Award the “E Craig Nemec Achievement Challenges – Austin Ventures” in the Venture Lab Investment Competition (VLIC) at Texas Austin on May 2011, with a Li Qing (PhD student in SPHPC) and a group of MBA students




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